INT162903

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A) signal transduction (PDE2A) Golgi apparatus (PDE2A)
endoplasmic reticulum (PDE2A) plasma membrane (PDE2A) nucleus (PDE2A)
PDE2A (Homo sapiens)
Pain Link Frequency Relevance Heat
5HT 13 99.60 Very High Very High Very High
nMDA receptor 30 98.96 Very High Very High Very High
gABA 28 85.92 High High
Glutamate 39 69.12 Quite High
Hippocampus 27 62.48 Quite High
Inflammation 2 50.00 Quite Low
Central nervous system 2 16.28 Low Low
headache 2 10.00 Low Low
long-term potentiation 10 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 25 86.68 High High
Post-traumatic Stress Disorder 88 75.36 Quite High
Stress 82 69.04 Quite High
Neurodegenerative Disease 7 55.92 Quite High
Traumatic Stress Disorders 5 50.00 Quite Low
INFLAMMATION 2 50.00 Quite Low
Panic Disorder 1 36.40 Quite Low
Anxiety Disorder 22 5.00 Very Low Very Low Very Low
Cognitive Disorder 9 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term DETA NONOate administration induced an immediate mRNA up-regulation of PDE5A (1.9-fold, 0.5 hour), an early peak of PDE2A (1.4-fold, 1 and 2 hours) and later up-regulation of both PDE3B (1.6-fold, 4 hours) and PDE2A (1.7-fold, 8 hours and 1.2-fold after 24 hours).
Localization (regulation) of PDE2A
1) Confidence 0.61 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
In addition, acute release of NO via nNOS and NMDA receptor activation down-regulates the NMDA receptor, while localized release of 5HT will attenuate the mobilization of Ca2+, NO, and cGMP (Marcoli et al 1997; Maura et al 2000).
Localization (mobilization) of cGMP associated with nmda receptor and 5ht
2) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.89 Pain Relevance 0.45

General Comments

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