INT162921

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE3B) signal transduction (PDE3B) Golgi apparatus (PDE3B)
endoplasmic reticulum (PDE3B)
PDE3B (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 37.16 Quite Low
headache 3 10.00 Low Low
Inflammation 38 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 2 85.60 High High
Disease 6 54.32 Quite High
Hypertension 5 51.20 Quite High
INFLAMMATION 44 5.00 Very Low Very Low Very Low
Pulmonary Disease 31 5.00 Very Low Very Low Very Low
Vomiting 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Natriuresis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term DETA NONOate administration induced an immediate mRNA up-regulation of PDE5A (1.9-fold, 0.5 hour), an early peak of PDE2A (1.4-fold, 1 and 2 hours) and later up-regulation of both PDE3B (1.6-fold, 4 hours) and PDE2A (1.7-fold, 8 hours and 1.2-fold after 24 hours).
Localization (regulation) of PDE3B
1) Confidence 0.60 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
PDE3A is located on chromosome 12p12 and PDE3B is located on chromosome 11p15.1 (Miki et al 1996; Kasuya et al 2000).
Localization (located) of PDE3B
2) Confidence 0.20 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.

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