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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NQO1) small molecule metabolic process (NQO1) oxidoreductase activity (NQO1)
cellular nitrogen compound metabolic process (NQO1) cytoplasm (NQO1)
Anatomy Link Frequency
endothelial cell 1
NQO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 98.48 Very High Very High Very High
metalloproteinase 1 93.60 High High
Analgesic 1 71.84 Quite High
cva 2 57.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 98.48 Very High Very High Very High
Disease 2 80.88 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 70.12 Quite High
Cancer 1 68.36 Quite High
Thrombosis Related Under Development 1 57.84 Quite High
Myocardial Infarction 1 52.80 Quite High
Cv General 3 Under Development 1 48.64 Quite Low
Arrhythmias 2 Under Development 1 47.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include recent insights into inhibiting cell proliferation by interfering with mitotic spindle microtubule function, decrease Matrix Metalloproteinase (MMP) activity, block the cell cycle in the S or G2/M phases to interfere with processes of cell division, suppress O2(-) generation in leukocytes, inhibit different protein kinases, modulate the signalings, induce carcinogen-detoxifying enzymes glutathione S-transferases (GSTs) and/or NAD(P)H quinine oxidoreductase (NQO1), suppress the phosphorylation of Akt/PKB as a mechanism inhibiting inflammation, progress in structure modification to increase in anti-fungal action, to broaden against bacteria spectrum, to enhance inhibiting activities of nitric oxide synthase (NOS) and cyclooxygenase (COX), to strengthen anti-oxidant activity and to exhibite a much higher cytotoxicity against human umbilical vein endothelial cell (HUVEC).
Phosphorylation (phosphorylation) of NQO1 in endothelial cell associated with inflammation and metalloproteinase
1) Confidence 0.69 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19754420 Disease Relevance 0.50 Pain Relevance 0.23

General Comments

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