INT162940

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tfap2a) Golgi apparatus (Tfap2a) nucleolus (Tfap2a)
nucleus (Tfap2a) transcription factor binding (Tfap2a) cytoplasm (Tfap2a)
Tfap2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
carbamazepine 2 99.98 Very High Very High Very High
depression 1 52.48 Quite High
fluoxetine 1 51.52 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 6 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon chronic administration, lithium and carbamazepine decrease the binding activity of activator protein-2 and, in turn, the transcription, translation and activity of its arachidonic acid-selective calcium-dependent phospholipase A(2) gene product, whereas chronic valproic acid non-competitively inhibits long-chain acyl-CoA synthetase.
Negative_regulation (decrease) of activator protein-2 associated with carbamazepine
1) Confidence 0.32 Published 2009 Journal Biochem. Soc. Trans. Section Abstract Doc Link 19754461 Disease Relevance 0.34 Pain Relevance 0.17

General Comments

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