INT162968

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A5) oxidoreductase activity (CYP3A5) endoplasmic reticulum (CYP3A5)
Anatomy Link Frequency
alveolar macrophages 2
CYP3A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 6 96.92 Very High Very High Very High
imagery 1 84.44 Quite High
abdominal pain 1 81.36 Quite High
methotrexate 1 78.16 Quite High
Nicotine 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 68 98.88 Very High Very High Very High
Toxicity 3 96.40 Very High Very High Very High
Lung Cancer 6 88.04 High High
Ileus 1 84.72 Quite High
Intestinal Pseudo-obstruction 2 83.20 Quite High
Constipation 1 82.52 Quite High
Abdominal Pain 1 81.36 Quite High
Epstein-barr Virus 1 74.52 Quite High
Infection 1 68.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ritonavir is a potent CYP3A5 isoenzyme and P-gp inhibitor.
Negative_regulation (inhibitor) of Gene_expression (isoenzyme) of CYP3A5
1) Confidence 0.40 Published 2009 Journal Pharm World Sci Section Abstract Doc Link 19757141 Disease Relevance 0.71 Pain Relevance 0.43
Previously, Hukkanen et al. (2003) demonstrated decreased CYP3A5 expression in alveolar macrophages of smokers.
Negative_regulation (decreased) of Gene_expression (expression) of CYP3A5 in alveolar macrophages associated with nicotine addiction
2) Confidence 0.29 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.94 Pain Relevance 0

General Comments

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