INT162992

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 3
Disease Relevance 0.25
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ephb1, Ppm1e) endosome (Ephb1) signal transduction (Ephb1)
nucleolus (Ppm1e) nucleus (Ppm1e) plasma membrane (Ephb1)
Anatomy Link Frequency
striatum 2
Ephb1 (Rattus norvegicus)
Ppm1e (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 21 98.50 Very High Very High Very High
Dopamine 3 89.08 High High
withdrawal 3 84.24 Quite High
opiate 3 81.72 Quite High
Disease Link Frequency Relevance Heat
Death 3 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity.
ERK Binding (binding) of partner in striatum associated with morphine
1) Confidence 0.03 Published 2010 Journal Eur Neuropsychopharmacol Section Title Doc Link 19758790 Disease Relevance 0.09 Pain Relevance 0.51
At SW 3, p-PEA-15, a FADD-ERK binding partner, was also upregulated (51%) as well as the activation of its phosphorylating Akt1 kinase (49%).
ERK Binding (binding) of partner
2) Confidence 0.03 Published 2010 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 19758790 Disease Relevance 0.06 Pain Relevance 0.74
The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity.
MEK/ERK Binding (binding) of partner in striatum associated with morphine
3) Confidence 0.01 Published 2010 Journal Eur Neuropsychopharmacol Section Title Doc Link 19758790 Disease Relevance 0.09 Pain Relevance 0.52

General Comments

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