INT162998

Context Info Confidence 0.71 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 12 Disease Relevance 1.52 Pain Relevance 0.52

cytosol (PDCD10) Golgi apparatus (PDCD10) plasma membrane (PDCD10) cytoplasm (PDCD10)

PDCD10 (Homo sapiens)

Pain Link Frequency Relevance Heat headache 12 89.96 cva 2 88.20 Central nervous system 24 82.88 withdrawal 10 75.08 imagery 20 44.16 Glutamate 20 5.00

Disease Link Frequency Relevance Heat Apoptosis 90 99.68 Stress 10 92.56 Headache 12 89.96 Hemorrhage 2 88.20 Epilepsy 2 87.68 Vascular Malformations 2 80.96 Adhesions 10 65.48 Convulsion 10 53.60 Stroke 20 52.04 Metastasis 10 39.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Similar to earlier observations, PDCD10 was found to function in apoptotic pathways since overexpression of PDCD10 induces apoptosis through the caspase 3 pathway [26].

Gene_expression (overexpression) of PDCD10 associated with apoptosis

1) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0.76 Pain Relevance 0.09

Production of recombinant PDCD10 protein was described previously [28].

Gene_expression (Production) of PDCD10

2) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

Recombinant murine 6xHis-PDCD10 was expressed in BL21 cells and purified by nickel affinity chromatography.

Gene_expression (expressed) of PDCD10

3) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

The overall theoretical structure of PDCD10 is an ?

Gene_expression (structure) of PDCD10

4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0.07 Pain Relevance 0

Examination of phospholipid and OSM binding using recombinant PDCD10 proteins

Gene_expression (proteins) of PDCD10

5) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

COS7 cells were transfected with WT PDCD10-mCherry, ?

Gene_expression (transfected) of PDCD10

6) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

We propose that PDCD10 functions closely with VEGFR2 and PI3K.

Spec (propose) Gene_expression (functions) of PDCD10

7) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

Examination of the tertiary and secondary structures of PDCD10

Gene_expression (structures) of PDCD10

8) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

The CCM genes are identified as Krit 1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3).

Gene_expression (identified) of CCM3

9) Confidence 0.55 Published 2010 Journal Neurosurg Rev Section Abstract Doc Link 19760287 Disease Relevance 0.35 Pain Relevance 0.21

The CCM genes are identified as Krit 1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3).

Gene_expression (identified) of PDCD10

10) Confidence 0.55 Published 2010 Journal Neurosurg Rev Section Abstract Doc Link 19760287 Disease Relevance 0.35 Pain Relevance 0.21

5KA PDCD10 were dialyzed in 10 mM phosphate buffer, pH 7.0 and 500 mM NaCl.

Gene_expression (dialyzed) of PDCD10

11) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

We expressed these recombinant mutant proteins along with wild-type PDCD10 with an N-terminal 6xHis-tag in bacteria as previously described [28].

Gene_expression (expressed) of PDCD10

12) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

General Comments

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