INT163035

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Context Info
Confidence 0.71
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.68
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (E2f1) nucleus (E2f1) DNA binding (E2f1)
transcription factor binding (E2f1) cytoplasm (E2f1)
Anatomy Link Frequency
motor neurons 2
E2f1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 99.68 Very High Very High Very High
Hippocampus 5 75.44 Quite High
mu opioid receptor 1 75.00 Quite High
narcan 1 74.24 Quite High
antagonist 4 72.48 Quite High
Spinal cord 155 50.00 Quite Low
Neurotransmitter 28 44.52 Quite Low
Central nervous system 51 44.00 Quite Low
Glutamate 18 21.88 Low Low
Inflammation 24 7.84 Low Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 100.00 Very High Very High Very High
Apoptosis 7 99.60 Very High Very High Very High
Disease 12 99.00 Very High Very High Very High
Injury 332 96.36 Very High Very High Very High
Cancer 44 95.16 Very High Very High Very High
Neurodegenerative Disease 33 85.60 High High
Glioma 24 79.48 Quite High
Repression 15 73.04 Quite High
Colon Cancer 1 72.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 83 68.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This database is at present not fully annotated for all know transcriptions factors, and at the time of writing TRANSFAC contained motifs for 6 of the 34 transcription factors encoded by genes identified in the present study as differentially expressed (SP1, E2F1, FOXO1, ATF3, ATF4, MYC).
Gene_expression (expressed) of E2F1
1) Confidence 0.71 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.25 Pain Relevance 0
The differentially expressed genes of SP1 (Sp1) and E2F1 (E2f1) belong to cluster 7, which show an early up-regulation that is maintained throughout the injury response.
Gene_expression (expressed) of E2F1 associated with injury
2) Confidence 0.71 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.10 Pain Relevance 0
The differentially expressed genes of SP1 (Sp1) and E2F1 (E2f1) belong to cluster 7, which show an early up-regulation that is maintained throughout the injury response.
Gene_expression (expressed) of E2f1 associated with injury
3) Confidence 0.71 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.10 Pain Relevance 0
The expression pattern of the genes coding for SP1, E2F1 and MYC together with their broad cluster targets suggest that these un-specific activators of transcription enhance the general transcriptional capacity of the motor neurons, while the expression pattern of genes coding for other more specific regulators of transcription like OLIG1 or NKX6-2 could function to shape the response by relief or activation of targeted suppression of specific sets of genes, supporting the hypothesis of suppressor mediated transcriptional specificity.
Gene_expression (expression) of E2F1 in motor neurons
4) Confidence 0.55 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.23 Pain Relevance 0
The expression pattern of the genes coding for SP1, E2F1 and MYC together with their broad cluster targets suggest that these un-specific activators of transcription enhance the general transcriptional capacity of the motor neurons, while the expression pattern of genes coding for other more specific regulators of transcription like OLIG1 or NKX6-2 could function to shape the response by relief or activation of targeted suppression of specific sets of genes, supporting the hypothesis of suppressor mediated transcriptional specificity.
Gene_expression (expression) of E2F1 in motor neurons
5) Confidence 0.55 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.23 Pain Relevance 0
Interestingly, cell cycle proteins, such as the transcription factor, E2F1, and its regulator, the retinoblastoma gene product, exhibit increased levels and altered expression patterns in Alzheimer’s Disease (AD), PD, and HAND postmortem tissue (Jordan-Sciutto et al. 2002a, b; Hoglinger et al. 2007).
Gene_expression (expression) of E2F1 associated with disease and retinoblastoma
6) Confidence 0.28 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.81 Pain Relevance 0.04
E2F1 expression remained unchanged, in contrast to previous findings in vitro, demonstrating the potential importance of the orthotopic tumour microenvironment on cell responses to GLA treatment [9].
Gene_expression (expression) of E2F1 associated with cancer
7) Confidence 0.22 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.96 Pain Relevance 0
With morphine treatment, the levels of both cytoplasmic and nuclear E2F1 which is the downstream effecter of AKT were elevated and the interaction of E2F1 with YY1, rather than Sp1, was also increased.
Gene_expression (levels) of E2F1 associated with morphine
8) Confidence 0.15 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19765550 Disease Relevance 0 Pain Relevance 0.43

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