INT163038

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (E2f1) nucleus (E2f1) DNA binding (E2f1)
transcription factor binding (E2f1) cytoplasm (E2f1)
Anatomy Link Frequency
motor neurons 1
E2f1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 94.72 High High
narcan 1 92.56 High High
antagonist 1 90.80 High High
mu opioid receptor 1 75.00 Quite High
Spinal cord 31 57.04 Quite High
ischemia 1 16.24 Low Low
Neurotransmitter 5 8.40 Low Low
Central nervous system 3 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 66 80.08 Quite High
Cv Unclassified Under Development 1 16.24 Low Low
Spinal Cord Injury 19 5.00 Very Low Very Low Very Low
Spasticity 18 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Paralysis 2 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly the non-specific general activator proteins SP1 and E2F1 have been shown to interact to promote transcription [45] and in motor neurons they can drive the transcription of the motor neuron specific transcription factor HB9 [46].
E2F1 Binding (interact) of in motor neurons
1) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.08 Pain Relevance 0.03
Subsequently, E2F1 triggered the transcription of the MOR gene through its enhanced ability to bind the element in promoter region of the MOR gene.
E2F1 Binding (bind) of
2) Confidence 0.09 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19765550 Disease Relevance 0 Pain Relevance 0.47

General Comments

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