INT163052

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 1.21
Pain Relevance 6.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Msn) nucleolus (Msn) plasma membrane (Msn)
cytoskeleton (Msn) nucleus (Msn) protein binding, bridging (Msn)
Anatomy Link Frequency
MSN 3
synapses 3
DA neuron 1
dendritic tree 1
Msn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 336 100.00 Very High Very High Very High
Dopamine 1127 99.98 Very High Very High Very High
Serotonin 28 99.98 Very High Very High Very High
Nucleus accumbens 344 99.88 Very High Very High Very High
GABAergic 85 99.20 Very High Very High Very High
monoamine 25 98.22 Very High Very High Very High
dopamine receptor 39 98.20 Very High Very High Very High
agonist 148 97.68 Very High Very High Very High
imagery 32 96.88 Very High Very High Very High
Action potential 57 94.16 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 212 98.68 Very High Very High Very High
Parkinson's Disease 20 70.24 Quite High
Drug Dependence 4 52.04 Quite High
Disease 4 49.68 Quite Low
Cognitive Disorder 4 25.44 Quite Low
Depression 7 24.68 Low Low
Arrhythmias 2 Under Development 7 21.92 Low Low
Anaerobic Bacterial Infections 14 5.00 Very Low Very Low Very Low
Decapitation 12 5.00 Very Low Very Low Very Low
Hypersensitivity 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the shell of the Acb, the dimensions of the dendritic tree of MSN ranged from 62 up to 375 ?
Regulation (dimensions) of MSN in dendritic tree associated with nucleus accumbens and pyramidal cell
1) Confidence 0.38 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0.07 Pain Relevance 0.56
The dimensions of the extending recurrent axon collaterals of MSN ranged from 275 up to 575 ?
Regulation (dimensions) of MSN associated with pyramidal cell
2) Confidence 0.38 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0.10 Pain Relevance 0.53
So, both D1- and D2-like receptors appear to be present presynaptically and are thus positioned to modulate MSN synapses.


Regulation (modulate) of MSN in synapses
3) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.33 Pain Relevance 0.45
Here, using perforated patch-clamp recordings, we investigated the alterations in MSN intrinsic excitability induced by dopamine depletion.
Spec (investigated) Regulation (alterations) of MSN in MSN associated with dopamine
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.05 Pain Relevance 0.17
As stated in the introduction, although the consequences of dopamine receptors activation on striatal neurons physiology have been the subject of numerous studies, the alterations of MSN intrinsic excitability resulting from dopamine depletion remain incompletely documented.
Regulation (alterations) of MSN in neurons associated with dopamine and dopamine receptor
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.07 Pain Relevance 0.23
As same changes were detected in dopamine depletion, this strongly suggests a pivotal, if not exclusive, role of this current in the alterations in MSN intrinsic excitability observed in this condition.
Regulation (alterations) of MSN associated with dopamine
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.32
This was not due to DA acting via other monoaminergic receptors [viz. [57]], as there were clear instances where norepinephrine and serotonin modulated MSN synaptic connections that showed modest DA modulation.
Regulation (modulated) of MSN associated with dopamine, serotonin and monoamine
7) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 1.11
Presynaptic D2 autoreceptors on DA neuron terminals inhibit DA release [71], D2 heteroreceptors on corticostriatal terminals inhibit glutamatergic inputs [72], and presynaptic D1 and D2 heteroreceptors on MSN terminals modulate GABAergic IPSCs [present results, and Refs. [9,73]].
Regulation (heteroreceptors) of MSN in DA neuron associated with dopamine and gabaergic
8) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.22 Pain Relevance 0.58
In postnatal nAcc cultures, we examined MSN-to-MSN synaptic connections and their modulation by DA.
Spec (examined) Regulation (modulation) of MSN associated with dopamine
9) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.15 Pain Relevance 0.23
MSN activity is also altered by acute exposure to psychostimulants and other dopamine agonists (Tschanz et al., 1991; Haracz et al., 1993; Pederson et al., 1997; Rebec et al., 1997; West et al., 1997; White and Kalivas, 1998).
Regulation (altered) of MSN associated with dopamine and agonist
10) Confidence 0.20 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC3017361 Disease Relevance 0 Pain Relevance 0.19
Moreover, a D2 receptor-mediated regulation of this current in MSN has been suggested previously [21], [22].
Regulation (regulation) of MSN
11) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.34
Our paired-pulse experiments provide evidence for presynaptic modulation of MSN-to-MSN connections in culture.
Regulation (modulation) of MSN
12) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.08 Pain Relevance 0.44
To examine DA modulation of individual MSN-to-MSN synapses, and to address the hypothesis that DA receptors show differential trafficking, we used postnatal cell culture to gain access to individual, identified MSN synapses.
Spec (examine) Regulation (modulation) of MSN in synapses associated with dopamine
13) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.07 Pain Relevance 0.53
To examine DA modulation of individual MSN-to-MSN synapses, and to address the hypothesis that DA receptors show differential trafficking, we used postnatal cell culture to gain access to individual, identified MSN synapses.
Spec (examine) Regulation (modulation) of MSN in synapses associated with dopamine
14) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.07 Pain Relevance 0.53
We have used inhibitors of PDE10A and quantitative measures of mRNA to demonstrate that PDE10A controls striatal gene expression by regulating MSN cyclic nucleotide signaling pathways.
Regulation (regulating) of MSN in MSN
15) Confidence 0.08 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 19765598 Disease Relevance 0 Pain Relevance 0.11

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