INT163053

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde10a) cytoplasm (Pde10a)
Pde10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 1 90.16 High High
Enkephalin 3 88.88 High High
Neuropeptide 1 87.92 High High
Disease Link Frequency Relevance Heat
Schizophrenia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although inhibition of PDE10A causes accumulation of both cAMP and cGMP, the increase in striatal cfos expression appears to depend on changes in cAMP, since the increase is present in mice deficient in nNOS which fail to increase cGMP in response to PDE10A inhibition.
Regulation (response) of Negative_regulation (inhibition) of PDE10A
1) Confidence 0.45 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 19765598 Disease Relevance 0 Pain Relevance 0.18

General Comments

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