INT163063

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.06
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 2
brains 1
cortex 1
microglia 1
hippocampus 1
C1qa (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 10 99.40 Very High Very High Very High
Eae 7 99.30 Very High Very High Very High
tolerance 31 98.68 Very High Very High Very High
Hippocampus 109 98.56 Very High Very High Very High
Sciatic nerve 1 92.12 High High
Dorsal horn 1 88.40 High High
Neuropathic pain 7 87.52 High High
Glutamate 1 82.92 Quite High
Inflammation 146 82.00 Quite High
Deafferentation 2 81.60 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 21 99.40 Very High Very High Very High
Asthma 1 99.32 Very High Very High Very High
Injury 32 99.30 Very High Very High Very High
Autoimmune Disease 4 98.60 Very High Very High Very High
Disease 228 97.44 Very High Very High Very High
Sprains And Strains 146 96.88 Very High Very High Very High
Infection 215 96.72 Very High Very High Very High
Aging 100 95.56 Very High Very High Very High
General Immunology 1 92.16 High High
Neuropathic Pain 8 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RT-PCR results indicated an increase in C1q mRNA that was more pronounced than the increased expression of GFAP mRNA ipsilateral to the injury in the dorsal spinal cord.
Positive_regulation (increase) of C1q in spinal cord associated with injury and spinal cord
1) Confidence 0.67 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19766105 Disease Relevance 0.57 Pain Relevance 0.64
Previous studies have shown that complement component C1q is upregulated in a range of neurodegenerative diseases including Alzheimer's disease (see for example Fonseca et al [118]).
Positive_regulation (upregulated) of C1q associated with disease and neurodegenerative disease
2) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.70 Pain Relevance 0.03
Surgical transection of the perforant pathway increased C1qB mRNA in the entorhinal cortex and hippocampus [106] and C9 immunoreactivity in the hippocampus [107].
Positive_regulation (increased) of C1q in hippocampus associated with hippocampus
3) Confidence 0.67 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.58 Pain Relevance 0.37
Thus the requirement of C1q and C3 for promoting intranasal tolerance is a new finding with therapeutic potential.
Positive_regulation (requirement) of C1q associated with tolerance
4) Confidence 0.48 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.35 Pain Relevance 0.18
Other components of the complement cascade were also upregulated in the Lee et al. study [47], including C1q A-chain, C1q B-chain, and C1q C-chain.
Positive_regulation (upregulated) of C1q
5) Confidence 0.45 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.86 Pain Relevance 0.12
RT-PCR analysis revealed that seven days after CCI, the mRNA levels of glial markers C1q and GFAP, as well as those of mGlu5 and mGlu3, but not mGlu7, were elevated in the lumbar spinal cord - ipsilateral to the injury.
Positive_regulation (elevated) of C1q in spinal cord associated with eae, injury and spinal cord
6) Confidence 0.45 Published 2009 Journal Pain Section Abstract Doc Link 19782473 Disease Relevance 0.74 Pain Relevance 0.47
Examination of two other genes noted to be increased early in FrCasE-infected mouse brains, C1qa and p21, did not show statistically different expression in FrCasE- versus Fr57E infected cells.
Positive_regulation (increased) of C1qa in brains
7) Confidence 0.33 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.75 Pain Relevance 0.05
Interestingly, complement component C1qa was elevated in both FrCasE and Fr57E-infected microglia, suggesting the possibility that MLV infection could mildly stimulate these cells.
Positive_regulation (elevated) of C1qa in microglia associated with infection
8) Confidence 0.29 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.76 Pain Relevance 0
Surgical transection of the perforant pathway increased C1qB mRNA in the entorhinal cortex and hippocampus [106] and C9 immunoreactivity in the hippocampus [107].
Positive_regulation (increased) of C1q in cortex associated with hippocampus
9) Confidence 0.23 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.58 Pain Relevance 0.37
Similarly, previous studies have shown that C1Q is up-regulated during LPS and IFN-?
Positive_regulation (regulated) of C1Q
10) Confidence 0.04 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1590031 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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