INT163064

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.51
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 4
synapse 4
neuronal 2
C1qa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 60 100.00 Very High Very High Very High
Inflammation 491 98.40 Very High Very High Very High
chemokine 14 97.92 Very High Very High Very High
Spinal cord 7 97.84 Very High Very High Very High
Sciatic nerve 2 92.12 High High
Eae 6 91.24 High High
Hippocampus 87 88.60 High High
Dorsal horn 2 88.40 High High
Neuropathic pain 10 83.16 Quite High
glial activation 2 72.36 Quite High
Disease Link Frequency Relevance Heat
Disease 307 99.24 Very High Very High Very High
Death 51 99.14 Very High Very High Very High
Injury 48 98.68 Very High Very High Very High
INFLAMMATION 531 98.40 Very High Very High Very High
Gliosis 3 98.28 Very High Very High Very High
Brain Injury 4 96.68 Very High Very High Very High
Infection 339 96.52 Very High Very High Very High
Amyloid Plaque 36 95.64 Very High Very High Very High
Cancer 9 92.40 High High
Necrosis 36 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of C1q raises questions about neuronal synapse remodeling or bystander cell death.
Positive_regulation (increased) of Gene_expression (expression) of C1q in synapse associated with death
1) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.95 Pain Relevance 0.09
Signaling from immature astrocytes appears to induce C1q expression in microglia and neurons and it was hypothesized that reactive astrocytes seen in brain injury may provide a similar signal, ultimately leading to synapse loss and neuronal death.
Spec (appears) Positive_regulation (induce) of Gene_expression (expression) of C1q in synapse associated with death and brain injury
2) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.73 Pain Relevance 0.03
In addition, there was increased expression of the Suppression of Cytokine Signaling (SOCS), CD36, and PD-1L genes and others including C1q.
Positive_regulation (increased) of Gene_expression (expression) of C1q associated with cytokine
3) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.47 Pain Relevance 0.13
Microarrays provide insight into the molecular pathogenesis of the processes in the outbred mice reflecting inflammation, attenuation of this inflammation by counter regulatory processes, neuronal cell death and potential remodeling of synapses with increased expression of C1q, as well as CD36, immunoglobin genes, GFAP, and PD-1L in these transcriptomes.
Positive_regulation (increased) of Gene_expression (expression) of C1q in neuronal associated with inflammation and death
4) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.12 Pain Relevance 0.28
The RT-PCR results indicated an increase in C1q mRNA that was more pronounced than the increased expression of GFAP mRNA ipsilateral to the injury in the dorsal spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of C1q in spinal cord associated with injury and spinal cord
5) Confidence 0.49 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19766105 Disease Relevance 0.63 Pain Relevance 0.70
These results were interpreted to suggest that in these animal models of AD, (1) early complement activation (as indicated by C1q deposition) in response to fibrillar A?
Positive_regulation (indicated) of Gene_expression (deposition) of C1q associated with disease
6) Confidence 0.49 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.35 Pain Relevance 0.10
The RT-PCR results indicated an increase in C1q mRNA that was more pronounced than the increased expression of GFAP mRNA ipsilateral to the injury in the dorsal spinal cord.
Positive_regulation (increase) of Gene_expression (expression) of C1q in spinal cord associated with injury and spinal cord
7) Confidence 0.49 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19766105 Disease Relevance 0.63 Pain Relevance 0.70
These cellular events are accompanied by increased expression of members of the complement pathway (C1q, C3b, C3a, membrane attack complex), cytokines and chemokines (interleukin-1?
Positive_regulation (increased) of Gene_expression (expression) of C1q associated with chemokine and cytokine
8) Confidence 0.11 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 1.30 Pain Relevance 0.19
Similarly, previous studies have shown that C1Q is up-regulated during LPS and IFN-?
Positive_regulation (up) of Gene_expression (is) of C1Q
9) Confidence 0.05 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1590031 Disease Relevance 0.16 Pain Relevance 0.04
Similarly, previous studies have shown that C1Q is up-regulated during LPS and IFN-?
Positive_regulation (during) of Gene_expression (is) of C1Q
10) Confidence 0.05 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1590031 Disease Relevance 0.16 Pain Relevance 0.04

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