INT163066

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 4.47
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 4
spinal cord 3
internal 2
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 15 99.86 Very High Very High Very High
Eae 20 99.78 Very High Very High Very High
Inflammation 47 98.40 Very High Very High Very High
Spinal cord 68 98.04 Very High Very High Very High
Morphine 57 97.68 Very High Very High Very High
Sciatic nerve 5 94.16 High High
Dorsal horn 5 90.44 High High
opiate 3 86.48 High High
Central nervous system 49 84.72 Quite High
Glutamate 14 83.88 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 22 99.86 Very High Very High Very High
Injury 58 99.78 Very High Very High Very High
Sprains And Strains 83 98.96 Very High Very High Very High
INFLAMMATION 50 98.40 Very High Very High Very High
Spinal Cord Injury 13 98.04 Very High Very High Very High
Toxocariasis 45 93.88 High High
Brain Injury 31 93.12 High High
Syndrome 5 84.64 Quite High
Cicatrix 3 83.92 Quite High
Pain 29 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative abundance of the MHCI-HC, c-Fos and GFAP mRNA transcripts was calculated relative to the mRNA levels of the internal reference gene ?
Transcription (abundance) of GFAP in internal
1) Confidence 0.69 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
The mRNA and protein of astrocytes were labeled with GFAP.
Transcription (labeled) of GFAP in astrocytes
2) Confidence 0.60 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19766105 Disease Relevance 0.57 Pain Relevance 0.64
1 exhibit a rapid and dose-dependent increase in the expression of GFAP mRNA, and this increase is translated into a change in the steady-state level of GFAP protein [45,46].
Transcription (expression) of GFAP
3) Confidence 0.59 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 1.29 Pain Relevance 0.27
The relative abundance of the MHCI-HC, c-Fos and GFAP mRNA transcripts was calculated relative to the mRNA levels of the internal reference gene ?
Transcription (transcripts) of GFAP in internal
4) Confidence 0.52 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
RT-PCR analysis revealed that seven days after CCI, the mRNA levels of glial markers C1q and GFAP, as well as those of mGlu5 and mGlu3, but not mGlu7, were elevated in the lumbar spinal cord - ipsilateral to the injury.
Transcription (levels) of GFAP in spinal cord associated with eae, injury and spinal cord
5) Confidence 0.52 Published 2009 Journal Pain Section Abstract Doc Link 19782473 Disease Relevance 0.73 Pain Relevance 0.47
However, qPCR and detailed analysis of mRNA sequence of Gfap and Mtap2 indicated that strain differences are limited to putative short transcript forms whose functional significance is not known (Figure 4).
Transcription (sequence) of Gfap associated with sprains and strains
6) Confidence 0.50 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.52 Pain Relevance 0.99
Our data revealed the abundance of GFAP in the white matter in SC1-3 following complete spinal cord transection in the mid-trunk region.
Transcription (abundance) of GFAP in spinal cord associated with spinal cord
7) Confidence 0.48 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.10 Pain Relevance 0.13
Dual labeling was performed as described in [48]; rat anti-mouse CD31 (BD Biosciences Pharmingen), rabbit anti-human IBA1 (Wako), monoclonal anti-mouse GFAP (Chemicon) and monoclonal anti-mouse NEUN (Chemicon) were diluted at 1?
Transcription (described) of GFAP
8) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.06 Pain Relevance 0
PLD4 mRNA expression was also distinguishable from glial fibrillary acidic protein (GFAP) mRNA expression in astrocytes (Fig. 4B-c, c', d and d'), neural stem cells, and radial glia in the SVZ (Fig. 4-d and d').
Transcription (expression) of GFAP in astrocytes
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0
In addition, the cells expressed mRNA of nestin, GFAP, Sox2, Pax6, and vimentin (Fig 2h).
Transcription (expressed) of GFAP
10) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0
PLD4 mRNA expression was also distinguishable from glial fibrillary acidic protein (GFAP) mRNA expression in astrocytes (Fig. 4B-c, c', d and d'), neural stem cells, and radial glia in the SVZ (Fig. 4-d and d').
Transcription (expression) of GFAP in astrocytes
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0
DNA microarray analysis showed significantly increased expression of a number of genes associated with inflammation and astrocytic activation in the spinal cords of rats that developed CNP. mRNA levels of glial fibrilary acidic protein (GFAP) and AQP4 significantly increased in CNP spinal cords of rats.
Transcription (levels) of GFAP in spinal cords associated with inflammation and neuropathic pain
12) Confidence 0.26 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.21 Pain Relevance 0.69
Differentiating cultures up-regulated mRNA for NeuroD1, a key transcription factor in the neuronal lineage (Fig. 5d) and also expressed mRNA for GFAP.
Transcription (expressed) of GFAP in GFAP
13) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0.03

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