INT163082

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.35
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT6) signal transduction (STAT6) nucleolus (STAT6)
nucleus (STAT6) cytoplasm (STAT6) signal transducer activity (STAT6)
Anatomy Link Frequency
monocytes 1
B cells 1
STAT6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 60 99.78 Very High Very High Very High
Inflammation 52 95.68 Very High Very High Very High
rheumatoid arthritis 308 95.24 Very High Very High Very High
corticosteroid 12 89.56 High High
methotrexate 56 80.96 Quite High
Osteoarthritis 128 78.28 Quite High
Arthritis 8 77.84 Quite High
cytokine 32 74.40 Quite High
metalloproteinase 4 72.92 Quite High
cINOD 8 70.16 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 488 98.20 Very High Very High Very High
INFLAMMATION 48 95.68 Very High Very High Very High
Experimental Arthritis 4 78.88 Quite High
Frailty 136 78.28 Quite High
Pressure And Volume Under Development 8 62.12 Quite High
Pain 8 61.60 Quite High
Disease 116 52.76 Quite High
Disease Progression 24 31.48 Quite Low
Autoimmune Disease 28 5.00 Very Low Very Low Very Low
Arthritis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Assuming that normal monocytes behave like monocytes from patients with aspirin-exacerbated respiratory disease, inhibition of IL-4-STAT6 might explain a mechanism in aspirin desensitization daily treatment, resulting in downregulation of production and responsiveness to cysteinyl leukotrienes.
Negative_regulation (inhibition) of IL-4-STAT6 in monocytes
1) Confidence 0.42 Published 2009 Journal J. Allergy Clin. Immunol. Section Body Doc Link 19767084 Disease Relevance 0 Pain Relevance 0
Additionally, LEF inhibits Th17 generation through inhibition of p-STAT6 [67] and we also observed reductions in p-STAT6 levels in patients on these medications.
Negative_regulation (inhibition) of p-STAT6 associated with leflunomide
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.57 Pain Relevance 0.72
Interestingly, the phospho-activation signatures for each drug were not identical and patients on LEF exhibited reductions in p-STAT6 in their CD20+ B cells and reduced p-PLC-?
Negative_regulation (reductions) of p-STAT6 in B cells associated with leflunomide
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.18 Pain Relevance 0.55
, p-STAT1, p-STAT3, p-STAT6 and p-ZAP70 mean fluorescent intensity (MFI) levels were significantly elevated in ERA patient PB subsets in all three cellular compartments.
Negative_regulation (intensity) of p-STAT6 associated with rheumatoid arthritis
4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.02 Pain Relevance 0.27
Additionally, LEF inhibits Th17 generation through inhibition of p-STAT6 [67] and we also observed reductions in p-STAT6 levels in patients on these medications.
Negative_regulation (reductions) of p-STAT6 associated with leflunomide
5) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.58 Pain Relevance 0.74

General Comments

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