INT1631

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Context Info
Confidence 0.36
First Reported 1979
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 49.22
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
liver 3
heart 3
body 2
endothelial cells 1
Hdl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 351 99.80 Very High Very High Very High
alcohol 68 99.48 Very High Very High Very High
Restless leg syndrome 3 99.36 Very High Very High Very High
rheumatoid arthritis 81 99.12 Very High Very High Very High
tolerance 65 98.88 Very High Very High Very High
Angina 59 97.32 Very High Very High Very High
Bile 80 97.10 Very High Very High Very High
cytokine 79 92.00 High High
antagonist 50 89.28 High High
addiction 9 86.48 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 5965 100.00 Very High Very High Very High
Coronary Heart Disease 922 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

149 100.00 Very High Very High Very High
Obesity 108 100.00 Very High Very High Very High
Nicotine Addiction 105 99.92 Very High Very High Very High
INFLAMMATION 408 99.80 Very High Very High Very High
Hypertriglyceridemia 68 99.80 Very High Very High Very High
Metabolic Syndrome 209 99.56 Very High Very High Very High
Increased Venous Pressure Under Development 297 99.36 Very High Very High Very High
Myocardial Infarction 359 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, to evaluate the association between low levels of high-density lipoprotein cholesterol (HDL-C) and elevated ratio of serum cholesterol to HDL-C with these outcomes.
high-density lipoprotein cholesterol Binding (association) of associated with disorder of lipid metabolism
1) Confidence 0.36 Published 1994 Journal JAMA Section Abstract Doc Link 7772105 Disease Relevance 0.56 Pain Relevance 0.10
Using univariate and multivariate analyses, the association between high density lipoprotein (HDL) cholesterol and coronary heart disease (CHD) incidence was investigated.
high density lipoprotein Binding (association) of in heart associated with coronary artery disease and disorder of lipid metabolism
2) Confidence 0.32 Published 1979 Journal Am. J. Epidemiol. Section Abstract Doc Link 222135 Disease Relevance 1.09 Pain Relevance 0
Diets that are very low in fat are associated with low HDL levels too.
HDL Binding (associated) of in fat associated with disorder of lipid metabolism
3) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.14 Pain Relevance 0
Once cholesterol gets associated with HDL, it becomes esterified through the action of another enzyme, LCAT.13 Cholesterol ester, thus produced, is, again, hydrophobic and it accumulates to the center of the lipoprotein molecule, producing mature HDL.14 Subsequently, the mature HDL is transported to the liver where it releases the cholesterol for excretion into the bile.
HDL Binding (associated) of in liver associated with bile and disorder of lipid metabolism
4) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.76 Pain Relevance 0.10
The basic purpose of the management of low HDL and related dyslipidemias is to reduce the risk of atherosclerosis and its sequelae.
HDL Binding (management) of associated with atherosclerosis and disorder of lipid metabolism
5) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 2.01 Pain Relevance 0
The ATP III reported that when a low HDL level is present in association with high levels of TG (200 to 499 mg/dL), secondary priority, right after achievement of LDL goals, must go to achieving the non-HDL goal.
HDL Binding (association) of associated with disorder of lipid metabolism
6) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.31 Pain Relevance 0
In recognition of the significant risk associated with low HDL levels, national guidelines now support raising HDL to reduce CHD risk once LDL goals are met.
HDL Binding (associated) of associated with coronary heart disease and disorder of lipid metabolism
7) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.54 Pain Relevance 0.06
In HATS, simvastatin and niacin combination therapy was compared with placebo in CHD patients with low HDL (?
HDL Binding (low) of associated with coronary heart disease and disorder of lipid metabolism
8) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.47 Pain Relevance 0
FXR participates in the regulation of bile acid synthesis, conjugation, and transport.62 It also enhances the expression of one of the enzymes, phospholipid transfer protein, involved in HDL formation, and lowers TG levels by inducing PPAR-?
HDL Binding (formation) of in bile associated with bile and disorder of lipid metabolism
9) Confidence 0.26 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.74 Pain Relevance 0.27
This activity was not related to the interaction between these two lipoproteins or to antioxidative properties of HDL.
HDL Binding (interaction) of associated with disorder of lipid metabolism
10) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.77 Pain Relevance 0.03
Apolipoproteins, lipids, and enzymes associated with HDL are implicated in these effects in vitro.
HDL Binding (associated) of associated with disorder of lipid metabolism
11) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.21 Pain Relevance 0.09
Two new aspects of the interaction between HDL and endothelial cells are stimulation of angiogenesis and cell motility and migration.
HDL Binding (interaction) of in endothelial cells associated with disorder of lipid metabolism
12) Confidence 0.25 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.34 Pain Relevance 0.04
The interaction between low HDL and hypertriglyceridemia requires special attention because such mixed dyslipidemia is associated with aggressive atherogenecity.
HDL Binding (interaction) of associated with hypertriglyceridemia and disorder of lipid metabolism
13) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.23 Pain Relevance 0
Niacin raises serum HDL levels by decreasing HDL catabolism in the liver by down-regulating the expression of the F1 moiety of F1F0 ATP synthetase, a holoparticle HDL receptor.
HDL Binding (catabolism) of in liver associated with disorder of lipid metabolism
14) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.12 Pain Relevance 0
While contemplating therapy, the ATP III recommends that the causes and associations of low HDL must be ascertained and treated to their target as the first step before considering specific therapy.
HDL Binding (associations) of associated with disorder of lipid metabolism
15) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.91 Pain Relevance 0
Management of low HDL
HDL Binding (Management) of associated with disorder of lipid metabolism
16) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.32 Pain Relevance 0
HDL, angiogenesis, and cell migration
HDL Binding (migration) of associated with disorder of lipid metabolism
17) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.35 Pain Relevance 0.04
Several clinical studies have demonstrated a close association between plasma levels of HDL and endothelium-dependent flow-mediated dilation (O'Connell and Genest 2001).
HDL Binding (association) of in endothelium associated with disorder of lipid metabolism
18) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.82 Pain Relevance 0
Although it is not clear whether HDL in its relation to angiogenesis induces the progression of atherosclerosis, the strong and specific angiogenic effect of HDL deserves attention in the development of therapeutic strategies to elevate plasma levels of these lipoproteins.


HDL Binding (relation) of in plasma associated with atherosclerosis and disorder of lipid metabolism
19) Confidence 0.19 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.04 Pain Relevance 0.16
The National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines recognize low HDL (1.03 mmol/L or 40 mg/dL) as an independent major risk factor for coronary heart disease and as a potential target for therapeutic intervention.
HDL Binding (recognize) of in heart associated with coronary heart disease and disorder of lipid metabolism
20) Confidence 0.17 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.94 Pain Relevance 0

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