INT163114

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 8.93
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GOT1) small molecule metabolic process (GOT1) biosynthetic process (GOT1)
carbohydrate metabolic process (GOT1) cellular nitrogen compound metabolic process (GOT1) lysosome (GOT1)
Anatomy Link Frequency
liver 2
muscle 2
GOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 2 93.56 High High
Inflammation 35 91.92 High High
Migraine 4 75.00 Quite High
psoriasis 2 74.80 Quite High
Bile 1 73.76 Quite High
abdominal pain 14 52.64 Quite High
methotrexate 53 51.96 Quite High
corticosteroid 4 51.48 Quite High
cINOD 1 50.80 Quite High
rheumatoid arthritis 56 50.00 Quite Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 15 99.90 Very High Very High Very High
Hypocalcemia 2 99.72 Very High Very High Very High
Anaemia 21 99.44 Very High Very High Very High
Fever 5 99.28 Very High Very High Very High
Viral Infection 4 98.78 Very High Very High Very High
Growth Problems 26 98.32 Very High Very High Very High
Dengue 71 98.22 Very High Very High Very High
Hepatitis C Virus Infection 31 97.96 Very High Very High Very High
Celiac Disease 130 97.76 Very High Very High Very High
Hepatotoxicity 12 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated serum transaminase levels were observed in 24.7% of patients.
Positive_regulation (Elevated) of Gene_expression (levels) of serum transaminase
1) Confidence 0.24 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768234 Disease Relevance 1.80 Pain Relevance 0.05
Short stature in 11 patients (10.9%), recurrent iron deficincy anemia in 16 patients (14.6%) and elevated transaminase levels in 1 patient (0.9%) were the only clinical features of CD.
Positive_regulation (elevated) of Gene_expression (levels) of transaminase associated with celiac disease, anaemia and growth problems
2) Confidence 0.21 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768234 Disease Relevance 1.16 Pain Relevance 0
To identify possible mechanisms of hepatotoxicity, we investigated liver function in vitro at > 170-fold of therapeutic C(max) levels, including cytotoxicity (lactate dehydrogenase, MTT, and ATP), transaminase activities (alanine aminotransferase and aspartate aminotransferase), albumin synthesis, urea and testosterone metabolism to assay for cytochrome P450 monooxygenase activity.
Positive_regulation (assay) of Gene_expression (activities) of transaminase in liver associated with hepatotoxicity
3) Confidence 0.09 Published 2009 Journal Toxicol. Sci. Section Abstract Doc Link 19770483 Disease Relevance 0.69 Pain Relevance 0.18
There were more patients on a TCZ-DMARD combination than on TCZ monotherapy (8 mg/kg) or MTZ monotherapy who had elevations in aspartate transaminase and alanine transaminase.52
Positive_regulation (elevations) of Gene_expression (alanine) of transaminase
4) Confidence 0.06 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.38 Pain Relevance 0.10
We were unable to investigate specific muscle enzymes or isoforms in this study, but creatine kinase levels are known to be elevated during the acute phase of dengue infection.27 In combination with other simple laboratory tests, transaminase levels, particularly AST levels, have been suggested as a potential marker to help differentiate dengue from other viral infections during the early febrile phase.28 However, mild-to-moderate increases in transaminase levels, with AST higher than ALT levels, are a non-specific finding that may be observed in a number of other infections such as typhoid fever and malaria29,30 and in alcohol-related hepatitis.26
Positive_regulation (increases) of Gene_expression (levels) of transaminase in muscle associated with viral infection, dengue, fever, hepatitis, typhoid fever, infection and alcohol
5) Confidence 0.05 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.41 Pain Relevance 0.05
The compound administered, intravenously or subcutaneously, 3 times weekly did demonstrate a significant decrease in HCV RNA levels for a small sub-group of participants, however: many of the patients experienced frequent elevations in hepatic transaminase levels, raising doubts about the suitability of this drug [124].


Positive_regulation (elevations) of Gene_expression (levels) of transaminase associated with hepatitis c virus infection
6) Confidence 0.03 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 2.06 Pain Relevance 0.12
Although the initial reports of GEM 91 clinical trials showed it to be well tolerated [117], its use was later discontinued because of dose-limiting thrombocytopenia and elevated serum transaminase levels.
Positive_regulation (elevated) of Gene_expression (levels) of transaminase associated with thrombocytopenia
7) Confidence 0.03 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.44 Pain Relevance 0

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