INT16314

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Context Info
Confidence 0.65
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 7.99
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR0B1) RNA binding (NR0B1) nucleus (NR0B1)
DNA binding (NR0B1) transcription factor binding (NR0B1) response to stress (NR0B1)
Anatomy Link Frequency
testis 3
pancreas 1
neuron 1
ovary 1
kidney 1
NR0B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
Dopamine 83 98.32 Very High Very High Very High
midbrain 20 98.20 Very High Very High Very High
Pain 16 96.32 Very High Very High Very High
agonist 15 89.92 High High
Stabbing pain 2 62.04 Quite High
tetrodotoxin 2 59.68 Quite High
Inflammation 31 5.00 Very Low Very Low Very Low
dexamethasone 21 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Hemorrhagic Conjunctivitis 292 100.00 Very High Very High Very High
Muscular Dystrophy 85 100.00 Very High Very High Very High
Adrenal Insufficiency 20 99.72 Very High Very High Very High
Disease 161 98.64 Very High Very High Very High
Conjunctivitis 4 94.40 High High
Sprains And Strains 48 88.80 High High
Turner's Syndrome 10 86.28 High High
Syndrome 25 84.52 Quite High
Pain 12 81.72 Quite High
Convulsion 5 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthesis of four new N,N-disubstituted derivatives of enkephalin analogs: All2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 5, Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 6, All2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 11 and Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 12 is reported. they were tested for agonistic and antagonistic activity.
Gene_expression (Synthesis) of Ahx associated with enkephalin
1) Confidence 0.65 Published 1991 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 1824127 Disease Relevance 0 Pain Relevance 0.24
Synthesis of four new N,N-disubstituted derivatives of enkephalin analogs: All2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 5, Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 6, All2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 11 and Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 12 is reported. they were tested for agonistic and antagonistic activity.
Gene_expression (Synthesis) of Ahx associated with enkephalin
2) Confidence 0.65 Published 1991 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 1824127 Disease Relevance 0 Pain Relevance 0.25
Synthesis of four new N,N-disubstituted derivatives of enkephalin analogs: All2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 5, Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 6, All2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 11 and Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 12 is reported. they were tested for agonistic and antagonistic activity.
Gene_expression (Synthesis) of Ahx associated with enkephalin
3) Confidence 0.65 Published 1991 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 1824127 Disease Relevance 0 Pain Relevance 0.25
Synthesis of four new N,N-disubstituted derivatives of enkephalin analogs: All2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 5, Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 6, All2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 11 and Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 12 is reported. they were tested for agonistic and antagonistic activity.
Gene_expression (Synthesis) of Ahx associated with enkephalin
4) Confidence 0.65 Published 1991 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 1824127 Disease Relevance 0 Pain Relevance 0.25
Analysis was performed using a DAX1 (NR0B1) probe (BAC RP11-1129A5), a GK probe (RP11-229K14), and a dystrophin probe (NRM52), which shares homology with exon 52 in the dystrophin gene.
Gene_expression (probe) of NR0B1
5) Confidence 0.57 Published 2008 Journal Journal of Medical Genetics Section Body Doc Link PMC2602739 Disease Relevance 0.41 Pain Relevance 0.08
We report a girl with a de novo deletion at Xp21.2 on the maternal chromosome, including DAX1, the GK gene and 3?
Gene_expression (gene) of DAX1
6) Confidence 0.57 Published 2008 Journal Journal of Medical Genetics Section Abstract Doc Link PMC2602739 Disease Relevance 0.18 Pain Relevance 0
We have confirmed that the cause of this girlÂ’s adrenal insufficiency was due to a DAX1 deletion on her maternal allele with skewed inactivation of her normal paternal allele.
Gene_expression (deletion) of DAX1 associated with adrenal insufficiency
7) Confidence 0.57 Published 2008 Journal Journal of Medical Genetics Section Body Doc Link PMC2602739 Disease Relevance 0.97 Pain Relevance 0
For example, the pair (AHC, NR0B1) is only found in two places in the test collection, in both cases separated by many unique words:
Gene_expression (pair) of NR0B1
8) Confidence 0.53 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.13 Pain Relevance 0
For example, the pair (AHC, NR0B1) is only found in two places in the test collection, in both cases separated by many unique words:
Gene_expression (pair) of AHC
9) Confidence 0.53 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.13 Pain Relevance 0
Thus, mineralocorticoid insufficiency may be the predominant presenting feature of X-linked AHC, although glucocorticoid deficiency usually emerges with time.20 21
Gene_expression (presenting) of AHC
10) Confidence 0.50 Published 2008 Journal Journal of Medical Genetics Section Body Doc Link PMC2602739 Disease Relevance 0.88 Pain Relevance 0.07
The mean and range of time between exposure and disease onset was also significantly shorter in larger family clusters (>3 AHC cases per family) than in smaller ones (<?
Gene_expression (cases) of AHC associated with acute hemorrhagic conjunctivitis and disease
11) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776508 Disease Relevance 0.70 Pain Relevance 0
Several characteristics of the 2007 outbreak suggest a foreign source for Taiwan's AHC epidemic.
Gene_expression (source) of AHC associated with acute hemorrhagic conjunctivitis
12) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776508 Disease Relevance 0.96 Pain Relevance 0
Approximately fourteen percent (14.32%) of parents surveyed identified the short message service (SMS) issued by the Taipei City Department of Health as their primary source of AHC information.
Gene_expression (source) of AHC associated with acute hemorrhagic conjunctivitis
13) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776508 Disease Relevance 0.31 Pain Relevance 0
Since 1981, when AHC was first detected in the Western Hemisphere, three major epidemics had occurred until 2003, all affecting the Caribbean.
Gene_expression (detected) of AHC associated with acute hemorrhagic conjunctivitis
14) Confidence 0.30 Published 2004 Journal MMWR Morb. Mortal. Wkly. Rep. Section Abstract Doc Link 15269699 Disease Relevance 0.45 Pain Relevance 0.10
Combining exon 1 with the alternative exon 2a results in the generation of DAX-1?
Gene_expression (generation) of DAX-1
15) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
is expressed at higher levels than DAX-1 in all tissues, except in the testis, where DAX-1 expression is higher [Hossain et al., 2004].
Gene_expression (expressed) of DAX-1 in testis
16) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.06 Pain Relevance 0
The canonical DAX-1 receptor is expressed in the adrenal gland, brain, fetal kidney, ovary, pancreas, and testis.
Gene_expression (expressed) of DAX-1 receptor in ovary
17) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
is expressed at higher levels than DAX-1 in all tissues, except in the testis, where DAX-1 expression is higher [Hossain et al., 2004].
Gene_expression (expression) of DAX-1 in testis
18) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.06 Pain Relevance 0
X-linked conditions, such as AHC, GKD and DMD, are usually found only in males since females can express sufficient levels of protein from the genes on their active X chromosome.
Gene_expression (express) of AHC associated with muscular dystrophy
19) Confidence 0.20 Published 2008 Journal Journal of Medical Genetics Section Body Doc Link PMC2602739 Disease Relevance 1.08 Pain Relevance 0
The virus neutralizing antibody analysis for 17 of 19 paired serum specimens showed a 4 fold or greater rise in neutralizing antibodies titer which provided further evidence that CA24v was the causative agent of the AHC outbreak in Yunnan (Table 1).
Gene_expression (outbreak) of AHC associated with acute hemorrhagic conjunctivitis
20) Confidence 0.14 Published 2010 Journal Virol J Section Body Doc Link PMC2901270 Disease Relevance 1.03 Pain Relevance 0.13

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