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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.19
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col18a1) extracellular region (Col18a1) cell adhesion (Col18a1)
proteinaceous extracellular matrix (Col18a1) structural molecule activity (Col18a1) extracellular matrix organization (Col18a1)
Anatomy Link Frequency
endothelial cells 1
skin 1
Col18a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 48 93.68 High High
Inflammation 92 91.84 High High
Antinociceptive 3 85.84 High High
cINOD 1 57.04 Quite High
rheumatoid arthritis 88 50.84 Quite High
cytokine 58 50.00 Quite Low
Analgesic 2 25.00 Low Low
Pain 2 25.00 Low Low
Arthritis 26 11.56 Low Low
psoriasis 44 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 34 100.00 Very High Very High Very High
Cancer 166 96.32 Very High Very High Very High
Multiple Sclerosis 57 93.68 High High
INFLAMMATION 98 91.84 High High
Disease 70 91.04 High High
Corneal Neovascularization 7 77.92 Quite High
Autoimmune Disease 33 77.60 Quite High
Rheumatoid Arthritis 89 50.84 Quite High
Melanoma 7 22.96 Low Low
Arthritis 16 11.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morin displayed significant inhibition of chick chorioallantoic membrane (CAM) angiogenesis and was able to increase the endostatin level in human umbilical vein endothelial cells (HUVECs).
Positive_regulation (increase) of endostatin in endothelial cells
1) Confidence 0.41 Published 2010 Journal Planta Med. Section Abstract Doc Link 19774509 Disease Relevance 0.17 Pain Relevance 0.24
In a study on early molecular events in SSc, COL7A1 and COL18A1 were found as putative biomarkers for early onset of SSc, both upregulated in fibroblasts from uninvolved skin lesions of SSc patients compared with controls [62].
Positive_regulation (upregulated) of COL18A1 in skin associated with systemic sclerosis
2) Confidence 0.31 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.11 Pain Relevance 0.22
In fact, endostatin and IL-12 levels were significantly higher in PPAR?
Positive_regulation (higher) of endostatin
3) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.92 Pain Relevance 0.06

General Comments

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