INT163189

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.31
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD27)
Anatomy Link Frequency
B cells 2
blood 1
joint 1
CD27 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 40 97.96 Very High Very High Very High
Inflammation 35 57.52 Quite High
Central nervous system 13 57.00 Quite High
spinal inflammation 5 50.00 Quite Low
imagery 19 16.96 Low Low
metalloproteinase 26 12.68 Low Low
chemokine 7 11.04 Low Low
intrathecal 14 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Shingles 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 138 99.88 Very High Very High Very High
Systemic Sclerosis 4 99.80 Very High Very High Very High
Syndrome 13 99.34 Very High Very High Very High
Systemic Lupus Erythematosus 254 98.52 Very High Very High Very High
Bacterial Infection 68 98.36 Very High Very High Very High
Low Back Pain 5 98.12 Very High Very High Very High
Demyelinating Disease 45 97.96 Very High Very High Very High
Exanthema 40 93.56 High High
Congenital Anomalies 12 93.12 High High
Herpes Zoster 204 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the group of patients suspected of CTD, the frequency of CD27++/CD20?
Localization (frequency) of CD27 associated with disease
1) Confidence 0.74 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.51 Pain Relevance 0
In the healthy control group, the mean frequency of CD27++/CD20?
Localization (frequency) of CD27
2) Confidence 0.74 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.67 Pain Relevance 0
Thus, the presence of serum ANAs itself does not coincide with increased numbers of IgD+ CD38++ transitional B cells and CD27++ PCs as characteristically seen in SLE patients.
Localization (numbers) of CD27 in B cells associated with systemic lupus erythematosus
3) Confidence 0.74 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.09 Pain Relevance 0
Analysis of peripheral blood from patients with primary Sjogren's syndrome and systemic sclerosis showed a predominance of CD27?
Localization (predominance) of CD27 in blood associated with syndrome and systemic sclerosis
4) Confidence 0.74 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.99 Pain Relevance 0
METHODS: We detected the proportions of CD19(+) B-cell, naive B-cell (CD19(+)CD27-), memory B-cell (CD19(+)CD27dim) and plasmablast (CD19(+)CD27high) in peripheral blood of 66 patients with AS (39 at active stage, 27 at stable stage; 35 patients with peripheral joint involvement, 31 patients with axial involvement alone), 30 patients with rheumatoid arthritis (RA) and 30 healthy volunteers using flow cytometry.
Localization (proportions) of CD27 in joint
5) Confidence 0.73 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19781326 Disease Relevance 0.19 Pain Relevance 0
Additional stainings, which were however only possible in a few MS patients (due to limited CSF amounts), indicated that the majority of CSF B cells belong to the CD19+CD27+ memory B cell subset, while only a minority are naïve CD19+CD27?
Localization (subset) of CD27 in B cells associated with multiple sclerosis
6) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.76 Pain Relevance 0.18
Analysis of BAL samples revealed an increased frequency of proliferating CD27+IgD?
Localization (frequency) of CD27
7) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.28 Pain Relevance 0
PBMCs and BAL cells were stained with antibodies directed against CD20, IgD and CD27 to distinguish between three subsets: CD27-IgD+ (most likely naïve), CD27+IgD+, and CD27+IgD?
Localization (directed) of CD27
8) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.80 Pain Relevance 0

General Comments

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