INT163204

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.04
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
spinal cord 2
astrocytes 2
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 4 99.78 Very High Very High Very High
Spinal cord 1 99.40 Very High Very High Very High
Neuropathic pain 2 88.48 High High
Inflammation 10 88.16 High High
Glutamate 1 83.88 Quite High
Analgesic 1 75.00 Quite High
Central nervous system 11 64.88 Quite High
allodynia 1 44.96 Quite Low
Hyperalgesia 1 42.56 Quite Low
antiallodynic 1 35.68 Quite Low
Disease Link Frequency Relevance Heat
Injury 20 99.78 Very High Very High Very High
Toxocariasis 45 94.52 High High
Brain Injury 29 93.76 High High
Neuropathic Pain 3 88.48 High High
INFLAMMATION 10 88.16 High High
Cicatrix 2 84.56 Quite High
Nervous System Injury 1 73.68 Quite High
Disease 20 56.72 Quite High
Targeted Disruption 5 55.84 Quite High
Hyperalgesia 1 42.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis revealed that seven days after CCI, the mRNA levels of glial markers C1q and GFAP, as well as those of mGlu5 and mGlu3, but not mGlu7, were elevated in the lumbar spinal cord - ipsilateral to the injury.
Positive_regulation (elevated) of Transcription (levels) of GFAP in spinal cord associated with eae, injury and spinal cord
1) Confidence 0.45 Published 2009 Journal Pain Section Abstract Doc Link 19782473 Disease Relevance 0.75 Pain Relevance 0.47
1 exhibit a rapid and dose-dependent increase in the expression of GFAP mRNA, and this increase is translated into a change in the steady-state level of GFAP protein [45,46].
Positive_regulation (increase) of Transcription (expression) of GFAP
2) Confidence 0.43 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 1.29 Pain Relevance 0.27
PLD4 mRNA expression was also distinguishable from glial fibrillary acidic protein (GFAP) mRNA expression in astrocytes (Fig. 4B-c, c', d and d'), neural stem cells, and radial glia in the SVZ (Fig. 4-d and d').
Positive_regulation (distinguishable) of Transcription (expression) of GFAP in astrocytes
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0

General Comments

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