INT16321

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Context Info
Confidence 0.72
First Reported 1991
Last Reported 2010
Negated 8
Speculated 7
Reported most in Body
Documents 111
Total Number 118
Disease Relevance 49.90
Pain Relevance 14.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd3e) signal transducer activity (Cd3e)
Anatomy Link Frequency
T cells 23
lymphocytes 12
NK cells 6
spleen 6
B cells 4
Cd3e (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 72 99.64 Very High Very High Very High
Inflammation 1045 99.60 Very High Very High Very High
cytokine 1071 99.20 Very High Very High Very High
Morphine 28 99.20 Very High Very High Very High
spastic colon 186 97.90 Very High Very High Very High
tolerance 59 97.32 Very High Very High Very High
depression 37 96.32 Very High Very High Very High
imagery 49 95.96 Very High Very High Very High
substance P 51 95.60 Very High Very High Very High
rheumatoid arthritis 877 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Delayed Graft Function 23 100.00 Very High Very High Very High
Cancer 1348 99.82 Very High Very High Very High
Influenza Virus Infection 155 99.80 Very High Very High Very High
INFLAMMATION 1084 99.60 Very High Very High Very High
Infection 1133 99.16 Very High Very High Very High
Cystitis 70 98.96 Very High Very High Very High
Disease 807 98.88 Very High Very High Very High
Targeted Disruption 103 98.62 Very High Very High Very High
Lymphatic System Cancer 353 98.58 Very High Very High Very High
Diabetes Mellitus 123 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD3(-)CD16(+)CD56(+), and CD3(+)CD25(+) were measured as percentages of total lymphocytes by flow cytometer at 5 time points.
Gene_expression (Expressions) of CD3 in lymphocytes
1) Confidence 0.72 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16487501 Disease Relevance 0.08 Pain Relevance 0
Expressions of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD3(-)CD16(+)CD56(+), and CD3(+)CD25(+) were measured as percentages of total lymphocytes by flow cytometer at 5 time points.
Gene_expression (Expressions) of CD3 in lymphocytes
2) Confidence 0.72 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16487501 Disease Relevance 0.08 Pain Relevance 0
Morphine also increased the proportion of cells expressing either the epsilon-chain of the CD3 complex or the IL-2R.
Gene_expression (expressing) of CD3 associated with morphine
3) Confidence 0.65 Published 1991 Journal J. Immunol. Section Abstract Doc Link 1824589 Disease Relevance 0.21 Pain Relevance 0.73
Furthermore, expression levels of surface Ig, CD3, CD4, and CD8, were similar in spleen cells from control or morphine-treated mice.
Gene_expression (expression) of CD3 in spleen associated with morphine
4) Confidence 0.63 Published 1995 Journal Immunol. Invest. Section Abstract Doc Link 7622200 Disease Relevance 0.25 Pain Relevance 0.73
Expressions of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD3(-)CD16(+)CD56(+), and CD3(+)CD25(+) were measured as percentages of total lymphocytes by flow cytometer at 5 time points.
Gene_expression (Expressions) of CD3 in lymphocytes
5) Confidence 0.63 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16487501 Disease Relevance 0.08 Pain Relevance 0
We, however, noticed that there were two subsets of CD3-positive cells that expressed CD3 at a high level (CD3high) or intermediate level (CD3int) (Fig. 5B).
Gene_expression (expressed) of CD3
6) Confidence 0.60 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.05 Pain Relevance 0
Expressions of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD3(-)CD16(+)CD56(+), and CD3(+)CD25(+) were measured as percentages of total lymphocytes by flow cytometer at 5 time points.
Gene_expression (Expressions) of CD3 in lymphocytes
7) Confidence 0.56 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16487501 Disease Relevance 0.08 Pain Relevance 0
A prospective randomized controlled trial was designed to observe expressions of T-lymphocyte subsets (CD3(+), CD3(+)CD4(+) and CD3(+)CD8(+)), natural-killer cells (CD3(-)CD16(+)CD56(+)), and activated T-lymphocytes (CD3(+)CD25(+)) of patients undergoing gastric cancer surgeries and receiving patient-controlled intravenous analgesia (PCIA).
Gene_expression (expressions) of CD3 in T-lymphocytes associated with stomach cancer and analgesia
8) Confidence 0.56 Published 2006 Journal Clin. Chim. Acta Section Abstract Doc Link 16487501 Disease Relevance 0.36 Pain Relevance 0.66
Expressions of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD3(-)CD16(+)CD56(+), and CD3(+)CD25(+) were measured as percentages of total lymphocytes by flow cytometer at 5 time points.
Gene_expression (Expressions) of CD3 in lymphocytes
9) Confidence 0.56 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16487501 Disease Relevance 0.08 Pain Relevance 0
As the result, a proportion of CD3int CD4high CD8- lymphocytes markedly increased in lethal-infection with the WR strain (23.5%) compared to uninfected controls (4.4%) at 5 days post-infection (Fig. 5D).
Gene_expression (proportion) of CD3int in lymphocytes associated with sprains and strains and infection
10) Confidence 0.52 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.12 Pain Relevance 0
We, however, noticed that there were two subsets of CD3-positive cells that expressed CD3 at a high level (CD3high) or intermediate level (CD3int) (Fig. 5B).
Gene_expression (expressed) of CD3int
11) Confidence 0.52 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.17 Pain Relevance 0
The expression of transcripts for the T cell marker CD3?
Gene_expression (expression) of CD3 in T cell
12) Confidence 0.51 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.19 Pain Relevance 0.17
Notwithstanding these differences in localization and lethality, we observed that these two tumor subsets shared many common biological features, including the expression of CD3 molecules, the heteroclite expression of CD4 and CD8 surface markers, the upregulation of proteins generally involved in proliferation (PCNA) and the lack of expression of TCR–induced markers (i.e., CD69).
Gene_expression (expression) of CD3 associated with cancer
13) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.84 Pain Relevance 0
As in the case of leukemia/lymphoma cells from the aforementioned tumor–bearing animals, these thymocytes expressed excess amounts of CD3+ (Figure 4A,B), were PCNA positive (Figure 4A), and showed a heterogeneous display of CD4 and CD8 surface molecules (Figure 4C and data not shown).
Gene_expression (expressed) of CD3 in thymocytes associated with leukemia, lymphatic system cancer and cancer
14) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.76 Pain Relevance 0
Consistent with these cytometry data, immunohistochemical analysis of tissue sections indicated that the tumor cells present in both hematopoietic and non–hematopoietic tissues displayed high levels of CD3 expression (Figure 2B).
Gene_expression (expression) of CD3 associated with cancer
15) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.14 Pain Relevance 0
Phenotypic expression of cell surface markers of T lymphocyte subsets (CD3+, CD3+ CD4+, CD3+ CD8+, and CD4+ / CD8+ ) and NK cell ( CD161+) in the spleen were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expression) of CD3 in spleen
16) Confidence 0.41 Published 2005 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 15898424 Disease Relevance 0.06 Pain Relevance 0
Again, we were not able to detect red fluorescent cells (unstained section, Figure 2a) or CD3+ (not shown) or CD4+ (Figure 2b) cells in these joints (sections of inflamed synovial tissue, shown in Figure 2, are from a SCID mouse with adoptively transferred acute arthritis in the ankle).
Gene_expression (detect) of CD3 in ankle associated with severe combined immunodeficiency and arthritis
17) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.71 Pain Relevance 0.13
In general, the distribution of CD3+CD8+, DX-5+, and CD11b+ lymphocytes changed little after CYP-induced cystitis.
Neg (little) Gene_expression (changed) of CD3 in lymphocytes associated with cystitis
18) Confidence 0.37 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.57 Pain Relevance 0.10
Cells were stained for DX5 and CD3 prior to quantifying by flow cytometry by comparison to a known quantity of CountBright Absolute counting beads (Molecular Probes, Invitrogen, USA) on a Cyan ADP LX 9 color flow cytometer (DAKO, UK).
Gene_expression (stained) of CD3
19) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827540 Disease Relevance 0 Pain Relevance 0
T cells and CD3+/CD69+ cells (**p < .01) in lung tissues significantly
Gene_expression (/) of CD3 in lung
20) Confidence 0.35 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.22 Pain Relevance 0.07

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