INT163217

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 0.62
Pain Relevance 5.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sstr2) plasma membrane (Sstr2) cytoplasm (Sstr2)
signal transducer activity (Sstr2)
Anatomy Link Frequency
neurons 3
Leydig cells 1
Sstr2 (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 27 99.68 Very High Very High Very High
Somatostatin 225 99.52 Very High Very High Very High
antagonist 10 96.48 Very High Very High Very High
agonist 19 96.00 Very High Very High Very High
gABA 3 93.76 High High
Glutamate receptor 3 92.56 High High
nMDA receptor antagonist 3 91.12 High High
tetrodotoxin 1 89.36 High High
Spinal cord 6 87.36 High High
Pain 3 86.16 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 89.52 High High
Pain 3 86.16 High High
Nociception 3 79.88 Quite High
Breast Cancer 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low
Facial Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, SSTR2 mRNA expression was detected on the SG neurons using single cell RT-PCR in juvenile mice.
Transcription (expression) of SSTR2 in neurons associated with substantia gelatinosa
1) Confidence 0.67 Published 2009 Journal Brain Res. Section Abstract Doc Link 19782664 Disease Relevance 0.17 Pain Relevance 1.27
SSTR2 mRNA was detected in 11 out of 28 (39%) SG neurons tested.
Transcription (detected) of SSTR2 in neurons associated with substantia gelatinosa
2) Confidence 0.67 Published 2009 Journal Brain Res. Section Abstract Doc Link 19782664 Disease Relevance 0.11 Pain Relevance 1.34
Of the somatostatin receptor subtypes, the sstr2 transcript was the most prevalent and detected in both males and females.
Transcription (transcript) of sstr2 associated with somatostatin
3) Confidence 0.64 Published 2010 Journal Endocrinology Section Abstract Doc Link 20410192 Disease Relevance 0.18 Pain Relevance 0.55
In addition, SSTR2 mRNA expression was detected on the SG neurons using single cell RT-PCR in juvenile mice.
Transcription (detected) of SSTR2 in neurons associated with substantia gelatinosa
4) Confidence 0.50 Published 2009 Journal Brain Res. Section Abstract Doc Link 19782664 Disease Relevance 0.17 Pain Relevance 1.27
A significant increase in sst2 receptor transcripts was observed in testosterone-treated cells.
Transcription (transcripts) of sst2
5) Confidence 0.11 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC151791 Disease Relevance 0 Pain Relevance 0.29
To approach a possible transcriptional regulation of sst2 receptor expression by testosterone, sst2 mRNAs were measured by semi-quantitative RT-PCR in the extracts obtained from cells cultured in the presence or in the absence of testosterone.
Spec (possible) Transcription (transcriptional) of sst2
6) Confidence 0.11 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0 Pain Relevance 0.21
To assess whether sst2 receptor expression might be regulated by testosterone, we performed a semi-quantitative RT-PCR analysis of sst2 mRNA expression in Leydig cells cultured in the presence or in the absence of the androgen.
Transcription (expression) of sst2 in Leydig cells
7) Confidence 0.11 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC151791 Disease Relevance 0 Pain Relevance 0.29
To approach a possible transcriptional regulation of sst2 receptor expression by testosterone, sst2 mRNAs were measured by semi-quantitative RT-PCR in the extracts obtained from cells cultured in the presence or in the absence of testosterone.
Spec (possible) Transcription (transcriptional) of sst2
8) Confidence 0.11 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0 Pain Relevance 0.21

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