INT16322

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 28
Disease Relevance 15.88
Pain Relevance 12.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 2
T cells 2
plasma 1
synovial fluid 1
erythrocyte 1
Il2rb (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 69 99.92 Very High Very High Very High
Kinase C 20 99.60 Very High Very High Very High
Arthritis 25 98.88 Very High Very High Very High
opiate 20 98.32 Very High Very High Very High
rheumatoid arthritis 11 97.86 Very High Very High Very High
spinal inflammation 18 97.20 Very High Very High Very High
corticosteroid 5 97.12 Very High Very High Very High
antagonist 9 96.36 Very High Very High Very High
Pain 14 95.84 Very High Very High Very High
psoriasis 13 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 396 99.86 Very High Very High Very High
Disease 237 99.32 Very High Very High Very High
Seronegative Spondarthritis 24 99.28 Very High Very High Very High
Cancer 79 98.84 Very High Very High Very High
Rheumatoid Arthritis 15 98.64 Very High Very High Very High
Necrosis 5 98.60 Very High Very High Very High
Low Back Pain 22 97.20 Very High Very High Very High
Arthralgia 13 95.84 Very High Very High Very High
Psoriasis 13 95.04 Very High Very High Very High
Skin Diseases 8 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of PMA-stimulated IL-2R expression was not reproduced by incubating splenocytes with morphine (10(-8)-10(-5) M).
Gene_expression (expression) of IL-2R associated with morphine
1) Confidence 0.51 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.53
Moreover, adrenalectomy abolished this effect of morphine in CD4+ but not CD8+ T cells, suggesting that the inhibitory effect of morphine on IL-2R expression in CD4+ T cells may be mediated through a morphine-induced increase in corticosteroid levels.
Gene_expression (expression) of IL-2R in T cells associated with corticosteroid and morphine
2) Confidence 0.51 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.55
Thus, opiate-induced immunosuppression may involve an inhibition of post-PKC events, especially IL-2R expression, as well as impairment of earlier events in the activation of immune cells such as the increase in [Ca2+]i.
Gene_expression (expression) of IL-2R in immune cells associated with kinase c and opiate
3) Confidence 0.51 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.39
In contrast, morphine treatment had no effect on PMA/calcium ionophore (A23187)-induced increase in IL-2 secretion, suggesting a selective inhibition of IL-2R expression.
Gene_expression (expression) of IL-2R associated with morphine
4) Confidence 0.51 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.35
Administration of morphine significantly inhibited the phorbol myristate acetate (PMA)-stimulated increase in interleukin-2 receptor (IL-2R) expression in both CD4+ and CD8+ mouse T cells.
Gene_expression (expression) of IL-2R in T cells associated with morphine
5) Confidence 0.51 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.08
This observation suggests that increases in expression of components of the IL-2R can be achieved by retinoids and rexinoids, and that may enhance the cytotoxicity of DD.
Gene_expression (expression) of IL-2R
6) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.45 Pain Relevance 0
Because of the specificity of the IL-2 domain, the DT mediated cytotoxic activity will predominately affect cells that express the IL-2 receptor (IL-2R).
Gene_expression (express) of IL-2R
7) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.72 Pain Relevance 0
Gorgun and Foss investigated the role of the rexinoids bexarotene (TargretinĀ®) and alitretinoin (PanretinĀ®) as modulators of high affinity IL-2R expression (Gorgun and Foss 2002).
Gene_expression (expression) of IL-2R
8) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.61 Pain Relevance 0
The effect on the IL-2R expression occurred at a relatively low dose of bexarotene of 150 mg/day.
Gene_expression (expression) of IL-2R
9) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.29 Pain Relevance 0
While all the patients with a significant response had evidence of IL-2R expression, the heterogeneity of this expression was striking and ranged from 40% to less than 5% in the analyzed samples.
Gene_expression (expression) of IL-2R
10) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 1.11 Pain Relevance 0
In addition, the authors point out that in CTCL there may be a background of activated lymphocytes that express IL-2R and may contribute to false positive result.
Gene_expression (express) of IL-2R in lymphocytes associated with lymphatic system cancer
11) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.90 Pain Relevance 0
As in previous trials, there was no relationship noted between the presence of IL-2R?
Gene_expression (presence) of IL-2R
12) Confidence 0.16 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.68 Pain Relevance 0
First, the development of more reliable reagents which permit the accurate identification of the high, low and intermediate affinity IL-2R will allow for the sub-classification of patients with CTCL (or other IL-2R expressing malignancies).
Gene_expression (expressing) of IL-2R associated with lymphatic system cancer
13) Confidence 0.16 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.71 Pain Relevance 0
It has been estimated that approximately 50% of CTCL cases express the IL-2R as demonstrated by immunohistochemical staining (Nichols et al 1997).


Gene_expression (express) of IL-2R associated with lymphatic system cancer
14) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 0.49 Pain Relevance 0
Morphine also increased the proportion of cells expressing either the epsilon-chain of the CD3 complex or the IL-2R.
Gene_expression (expressing) of IL-2R associated with morphine
15) Confidence 0.12 Published 1991 Journal J. Immunol. Section Abstract Doc Link 1824589 Disease Relevance 0.21 Pain Relevance 0.74
Using an enzyme-linked immunoabsorbent assay (ELISA), we evaluated soluble IL-2R levels in the serum of 34 patients with RA and in the synovial fluid of 25 of these patients and we compared it with levels found in the serum of 13 healthy controls.
Gene_expression (levels) of IL-2R in synovial fluid associated with rheumatoid arthritis
16) Confidence 0.02 Published 1994 Journal Rheumatol. Int. Section Abstract Doc Link 7824835 Disease Relevance 0.66 Pain Relevance 0.05
In these mice lacking Tyro-3 receptors, elevated expressions of IL-2R, CD69, Fas, and IFN?
Gene_expression (expressions) of IL-2R
17) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 0.47 Pain Relevance 0.15
The levels of IL-1beta, IL-2R, TNF-alpha, IL-6 and IL-8 were measured in seminal plasma using chemiluminescence.
Gene_expression (levels) of IL-2R in plasma
18) Confidence 0.01 Published 2001 Journal Int. J. Urol. Section Body Doc Link 11683970 Disease Relevance 0.09 Pain Relevance 0
The presence of two or three of the following three items in patients with joint pain without any bone and joint destruction was thus indicated to be useful for the early diagnosis of RA: elevated CRP level (> or = 1.0 mg/dl), positive rheumatoid factor (RF) (> or = 30 IU/ml) and an elevated sIL-2R level (> or = 100 pmol/l).
Gene_expression (level) of sIL-2R in joint associated with pain, arthralgia and rheumatoid arthritis
19) Confidence 0.01 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9776115 Disease Relevance 1.07 Pain Relevance 0.68
The mean concentration of sIL-2R in the CSF was 65 kU/l (normal, < 50 kU/l) 5 weeks after treatment, whereas in all subsequent investigations sIL-2R was undetectable.
Gene_expression (undetectable) of sIL-2R
20) Confidence 0.01 Published 1995 Journal Neurology Section Abstract Doc Link 7898711 Disease Relevance 0.51 Pain Relevance 0.08

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