INT163221

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Context Info
Confidence 0.81
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.18
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt18) microtubule organizing center (Krt18) cytoplasm (Krt18)
Anatomy Link Frequency
liver 1
cleavage 1
Krt18 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 10 99.54 Very High Very High Very High
Inflammatory response 1 98.12 Very High Very High Very High
Inflammation 4 94.04 High High
fibrosis 8 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 27 99.90 Very High Very High Very High
INFLAMMATION 4 97.76 Very High Very High Very High
Hepatotoxicity 5 96.32 Very High Very High Very High
Liver Disease 15 94.44 High High
Death 4 93.72 High High
Necrosis 4 84.48 Quite High
Injury 7 82.80 Quite High
Disease 17 80.92 Quite High
Malignant Neoplastic Disease 1 80.56 Quite High
Cancer 2 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of APAP-induced apoptosis and K18 cleavage by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone are associated with increased hepatic damage, by a shift to necrotic cell death only.
Protein_catabolism (cleavage) of K18 in cleavage associated with paracetamol, apoptosis and death
1) Confidence 0.81 Published 2009 Journal Toxicol. Sci. Section Abstract Doc Link 19783637 Disease Relevance 1.16 Pain Relevance 0.56
The cleavage of human K18 at Asp396 can be monitored using the M30 antibody (Leers et al. 1999) and M30-Ab ELISA has become a useful serologic test for determining liver disease severity.
Protein_catabolism (cleavage) of K18 in liver associated with liver disease
2) Confidence 0.47 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.02 Pain Relevance 0

General Comments

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