INT163222

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Context Info
Confidence 1.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
cleavage 1
a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 99.46 Very High Very High Very High
Inflammatory response 1 97.96 Very High Very High Very High
Inflammation 1 93.88 High High
agonist 4 47.84 Quite Low
melanocortin 1 receptor 29 30.16 Quite Low
Kinase C 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 99.82 Very High Very High Very High
INFLAMMATION 2 97.60 Very High Very High Very High
Hepatotoxicity 3 96.16 Very High Very High Very High
Death 2 96.00 Very High Very High Very High
Necrosis 4 84.32 Quite High
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Vibrio Infection 3 5.00 Very Low Very Low Very Low
Microphthalmia 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To exclude the possibility that ASIP-YY is rapidly degraded in serum-containing medium, 100 nM ASIP or 100 nM ASIP-YY were incubated with culture medium containing 10% fetal bovine serum (FBS) at 37°C overnight and the mixture was used as stimulating buffer for cAMP measurements.
Protein_catabolism (degraded) of ASIP-YY
1) Confidence 1.00 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0
The inhibition of APAP-induced apoptosis and K18 cleavage by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone are associated with increased hepatic damage, by a shift to necrotic cell death only.
Protein_catabolism (cleavage) of Asp in cleavage associated with paracetamol, apoptosis and death
2) Confidence 0.86 Published 2009 Journal Toxicol. Sci. Section Abstract Doc Link 19783637 Disease Relevance 1.17 Pain Relevance 0.56

General Comments

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