INT163227

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.10
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dentin 3
tooth 1
Dspp (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 99.08 Very High Very High Very High
dexamethasone 3 87.60 High High
Calcium channel 1 63.12 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 1 99.08 Very High Very High Very High
Systemic Lupus Erythematosus 96 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Immune System Diseases 12 5.00 Very Low Very Low Very Low
Autoimmune Disease 12 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Hypercalcemia 6 5.00 Very Low Very Low Very Low
Graft Vs Host Disease 6 5.00 Very Low Very Low Very Low
Osteoporosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Gene_expression (expression) of dentin sialoprotein in dentin
1) Confidence 0.43 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Gene_expression (expression) of DSP in dentin
2) Confidence 0.43 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Gene_expression (levels) of DSP in dentin
3) Confidence 0.33 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
Based on the hypothesis that the primary cilium is crucial both for dentin formation and possibly in tooth pain transmission, we have investigated the expression and localization of the main cilium components and involvement of the OFD1 gene in tooth morphogenesis.
Gene_expression (formation) of dentin in tooth associated with pain
4) Confidence 0.05 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19783798 Disease Relevance 0.10 Pain Relevance 0.13

General Comments

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