INT163245

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.96
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (SRR) lyase activity (SRR) aging (SRR)
plasma membrane (SRR) cytoplasm (SRR)
Anatomy Link Frequency
astrocytes 1
skin 1
SRR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 94.04 High High
psoriasis 1 92.60 High High
cytokine 2 92.08 High High
imagery 7 75.84 Quite High
cINOD 1 68.08 Quite High
diclofenac 1 65.52 Quite High
Hippocampus 6 37.68 Quite Low
tetrodotoxin 6 14.88 Low Low
nMDA receptor 18 5.00 Very Low Very Low Very Low
Glutamate 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 99.72 Very High Very High Very High
Disease Progression 2 99.24 Very High Very High Very High
Reprotox - General 1 1 98.32 Very High Very High Very High
Cardiovascular Disease 1 96.12 Very High Very High Very High
Convulsion 1 95.32 Very High Very High Very High
Disease 39 94.32 High High
INFLAMMATION 14 94.04 High High
Chronic Renal Failure 1 93.72 High High
Psoriasis 1 92.60 High High
Systemic Lupus Erythematosus 1 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
F(2)-IsoPs were elevated about 100-fold after iron/ascorbate-induced oxidative stress and 2- to 4-fold after pentylenetetrazol (PTZ)-induced seizures, in hemodialysis patients with end stage renal disease, in psoriasis patients, in HaCaT keratinocytes, and in microdialysates of human skin following UVB irradiation.Both human and experimental studies have indicated associations of F(2)-IsoPs and inflammatory conditions.
Gene_expression (elevated) of IsoPs in skin associated with stress, psoriasis, chronic renal failure, convulsion and inflammation
1) Confidence 0.55 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19784591 Disease Relevance 0.89 Pain Relevance 0.19
This racemase is known to be expressed in protoplasmic astrocytes in vivo.
Gene_expression (expressed) of racemase in astrocytes
2) Confidence 0.01 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.07 Pain Relevance 0
-methylacyl CoA racemase expression as a predictor of disease progression in prostate cancer.
Gene_expression (expression) of racemase associated with reprotox - general 1 and disease progression
3) Confidence 0.01 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996064 Disease Relevance 1.00 Pain Relevance 0.22

General Comments

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