INT163253

Context Info Confidence 0.31 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 3.60 Pain Relevance 0.32

cytoplasmic membrane-bounded vesicle (Flg) cytoskeleton organization (Flg)

Anatomy Link Frequency skin 2 immune system 1 Flg (Mus musculus)

Pain Link Frequency Relevance Heat Pain 3 96.48 cytokine 11 95.32 Inflammatory response 5 90.56 Inflammation 17 73.52 headache 1 30.04 agonist 3 27.52 chemokine 3 5.00

Disease Link Frequency Relevance Heat Francisella Infection 58 100.00 Ichthyosis Vulgaris 6 100.00 Eczema 2 99.76 Sprains And Strains 38 96.40 Ichthyosis 2 91.12 Pachyonychia Congenita 12 91.08 INFLAMMATION 22 90.20 Alopecia Areata 2 89.92 Infection 47 88.24 Death 3 54.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Loss-of-function mutations in the filaggrin (FLG) gene underlie the most prevalent skin disorder of cornification, ichthyosis vulgaris (IV), which presents with generalized scaling and is also associated with atopic dermatitis.

FLG Binding (associated) of in skin associated with ichthyosis vulgaris and eczema

1) Confidence 0.31 Published 2009 Journal Br. J. Dermatol. Section Abstract Doc Link 19785597 Disease Relevance 0.90 Pain Relevance 0.10

Loss-of-function mutations in the filaggrin (FLG) gene underlie the most prevalent skin disorder of cornification, ichthyosis vulgaris (IV), which presents with generalized scaling and is also associated with atopic dermatitis.

filaggrin Binding (associated) of in skin associated with ichthyosis vulgaris and eczema

2) Confidence 0.31 Published 2009 Journal Br. J. Dermatol. Section Abstract Doc Link 19785597 Disease Relevance 0.90 Pain Relevance 0.10

Interaction of Ft with cells of the innate immune system (macrophages, dendritic cells, neutrophils, NK cells) initiates a cascade of cytokine production including IFN-?

Ft Binding (Interaction) of in immune system associated with francisella infection and cytokine

3) Confidence 0.28 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.80 Pain Relevance 0.13

General Comments

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