INT163269

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.20
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il23a) extracellular region (Il23a)
Anatomy Link Frequency
macrophages 1
monocytes 1
Salivary gland 1
T cells 1
Il23a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 267 100.00 Very High Very High Very High
spinal inflammation 17 99.08 Very High Very High Very High
Inflammation 137 98.64 Very High Very High Very High
Angina 3 97.96 Very High Very High Very High
antagonist 23 97.28 Very High Very High Very High
agonist 14 84.00 Quite High
Arthritis 106 68.32 Quite High
psoriasis 187 66.80 Quite High
Crohn's disease 9 65.20 Quite High
rheumatoid arthritis 62 41.44 Quite Low
Disease Link Frequency Relevance Heat
Asthma 104 99.84 Very High Very High Very High
Syndrome 12 99.30 Very High Very High Very High
Low Back Pain 17 99.08 Very High Very High Very High
Injury 12 98.92 Very High Very High Very High
INFLAMMATION 144 98.64 Very High Very High Very High
Cv General 3 Under Development 3 97.96 Very High Very High Very High
Disease 191 96.76 Very High Very High Very High
Myocardial Infarction 4 96.56 Very High Very High Very High
Rhinitis 3 94.68 High High
Acute Coronary Syndrome 2 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-23 was found to be expressed by several activated human cells like monocytes, macrophages, DCs, T cells, B cells and endothelial cells.22,23 IL-23 binds to its heterodimeric receptor complex composed of the IL-12R?
IL-23 Binding (binds) of in macrophages
1) Confidence 0.44 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.46 Pain Relevance 0.17
IL-23 was found to be expressed by several activated human cells like monocytes, macrophages, DCs, T cells, B cells and endothelial cells.22,23 IL-23 binds to its heterodimeric receptor complex composed of the IL-12R?
IL-23 Binding (binds) of in monocytes
2) Confidence 0.15 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.46 Pain Relevance 0.17
Genetic and genomic studies have demonstrated involvement of the interleukin-23 (IL-23) signaling pathway in AS, a finding which has stimulated much new research into the disease and has led to therapeutic trials.
interleukin-23 Binding (involvement) of associated with spinal inflammation and disease
3) Confidence 0.12 Published 2010 Journal Immunol. Rev. Section Abstract Doc Link 20192999 Disease Relevance 0.95 Pain Relevance 0.55
Genetic and genomic studies have demonstrated involvement of the interleukin-23 (IL-23) signaling pathway in AS, a finding which has stimulated much new research into the disease and has led to therapeutic trials.
IL-23 Binding (involvement) of associated with spinal inflammation and disease
4) Confidence 0.12 Published 2010 Journal Immunol. Rev. Section Abstract Doc Link 20192999 Disease Relevance 0.95 Pain Relevance 0.55
Salivary gland biopsy specimens from SS patients revealed strong positive staining for both IL-17 and IL-23 within lymphocytic foci and diffuse staining on epithelial tissues.
IL-23 Binding (staining) of in Salivary gland associated with syndrome
5) Confidence 0.11 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.32 Pain Relevance 0.18
IL-23 is composed of the IL-12p40 and a p19 subunit and likewise binds to a receptor with one of the IL-12 receptor subunits (IL-12R?
IL-23 Binding (binds) of
6) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.44 Pain Relevance 0.25
An in vitro study performed by Cheung et al. further suggested a role for IL-23 in asthma pathogenesis.
IL-23 Binding (role) of associated with asthma
7) Confidence 0.07 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.83 Pain Relevance 0.05
After this second signal, the T cells become activated, and APCs begin to secrete important cytokines, including IL-12 and IL-23, which bind to specific receptors on T cells and drive them to secrete different cytokines, such as IFN-?
IL-23 Binding (bind) of in T cells associated with cytokine
8) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0 Pain Relevance 0.17
A related cytokine, IL-23, is composed of the same p40 subunit covalently bound to a unique p19 subunit [53, 54].
IL-23 Binding (bound) of associated with cytokine
9) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.31 Pain Relevance 0.29
A number of agents which antagonize the IL-12/IL-23 axis appear to offer promise.
IL-23 Binding (antagonize) of
10) Confidence 0.06 Published 2009 Journal Dig Dis Section Abstract Doc Link 19786766 Disease Relevance 0.55 Pain Relevance 0.28
its cytokines (IL-17, IL-6, and IL-23) and transcription factor (RORgammat)
IL-23 Binding (cytokines) of associated with cytokine
11) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.95 Pain Relevance 0.48

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