INT163277

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 10.77
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CAV1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
Golgi apparatus (CAV1) endoplasmic reticulum (CAV1) intracellular (CAV1)
Anatomy Link Frequency
colon 2
fibroblasts 2
HPAF-II 2
BxPC-3 2
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 28 91.00 High High
cINOD 1 80.88 Quite High
fibrosis 14 27.44 Quite Low
Chronic pancreatitis 28 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 337 99.96 Very High Very High Very High
Adenocarcinoma 714 99.84 Very High Very High Very High
Sarcoma 2 99.70 Very High Very High Very High
Colon Cancer 6 99.46 Very High Very High Very High
Breast Cancer 16 99.28 Very High Very High Very High
Cancer 522 98.62 Very High Very High Very High
Targeted Disruption 16 95.12 Very High Very High Very High
Inflammatory Breast Neoplasms 28 91.56 High High
Skin Cancer 15 85.92 High High
Malignant Neoplastic Disease 8 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When cav-1 expression is diminished or lost, the p38 MAPK pathway is favored and cell migration occurs.
Negative_regulation (diminished) of Gene_expression (expression) of cav-1
1) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.23 Pain Relevance 0.04
Similarly in a Matrigel invasion assay, re-expression of cav-1 in the HPAF-II cells decreased the invasiveness of the cells nearly 2-fold compared with the controls.
Negative_regulation (decreased) of Gene_expression (expression) of cav-1 in HPAF-II
2) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.29 Pain Relevance 0
Here we present evidence for the involvement of RhoC GTPase and p38 MAPK in the migratory and invasive phenotype after loss of cav-1 expression in PC cells.
Negative_regulation (loss) of Gene_expression (expression) of cav-1 associated with adenocarcinoma
3) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.20 Pain Relevance 0
When cav-1 expression is diminished or lost, the p38 MAPK pathway is favored and cell migration occurs.
Negative_regulation (lost) of Gene_expression (expression) of cav-1
4) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.23 Pain Relevance 0.04
With these studies in mind we next examined whether RhoC can activate p42/p44 Erk in PC, subsequently decreasing cav-1 expression and leading to increased cellular migration.
Negative_regulation (decreasing) of Gene_expression (expression) of cav-1 associated with adenocarcinoma
5) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0.05
For example, initial “gain of function” studies of Cav-1 ectopically expressed in breast cancer cells grown in vitro suggested that Cav-1 has tumor suppressor functions.83 Similar in vitro studies also suggested a tumor suppressor role for Cav-1 in colon cancer and sarcoma cell lines.84 Cav-1 expression is also reduced in primary human breast cancers, colon cancers, and sarcomas, consistent with the notion that Cav-1 functions as a tumor suppressor in these tumor types.84
Negative_regulation (reduced) of Gene_expression (expression) of Cav-1 in colon associated with sarcoma, cancer, colon cancer and breast cancer
6) Confidence 0.55 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.42 Pain Relevance 0
Our results suggest that a combination of lovastatin and/or celecoxib suppressed caveolin-1 expression and membrane localization profoundly when compared to either agent alone.
Negative_regulation (suppressed) of Gene_expression (expression) of caveolin-1
7) Confidence 0.41 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.39 Pain Relevance 0.08
In contrast, loss of cav-1 expression leads to RhoC-mediated migration and invasion in metastatic PC cells.



Negative_regulation (loss) of Gene_expression (expression) of cav-1 associated with adenocarcinoma
8) Confidence 0.41 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1173138 Disease Relevance 0.98 Pain Relevance 0
The same studies also suggested a role for active protein kinase A (PKA) in reversibly suppressing cav-1 expression [38,39].
Negative_regulation (suppressing) of Gene_expression (expression) of cav-1
9) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.70 Pain Relevance 0.04
Cav-1 expression was slightly less after PD98059 treatment in both PC cell lines.
Negative_regulation (less) of Gene_expression (expression) of Cav-1 associated with adenocarcinoma
10) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.30 Pain Relevance 0
Loss of cav-1 expression leads to increased RhoC activation favoring the p38 MAPK pathway and cellular migration and invasion.
Negative_regulation (Loss) of Gene_expression (expression) of cav-1
11) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.77 Pain Relevance 0.03
Compared with the controls, transient ectopic re-expression of cav-1 decreased levels of active RhoC by 6-fold without effecting total RhoC protein levels, suggesting regulation of RhoC activation by cav-1.
Negative_regulation (decreased) of Gene_expression (expression) of cav-1
12) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0
In a tumor progression model of breast cancer, loss of cav-1 corresponded to increased metastasis, while ectopic expression of cav-1 inhibited metastasis[8].
Negative_regulation (inhibited) of Gene_expression (expression) of cav-1 associated with cancer, breast cancer and metastasis
13) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.23 Pain Relevance 0
That same group also demonstrated that ectopic re-expression of cav-1 decreased Erk activation in Ras-transformed CHO cells [39].
Negative_regulation (decreased) of Gene_expression (expression) of cav-1
14) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.25 Pain Relevance 0.05
Figure 1C demonstrates that ectopic re-expression of cav-1 to levels similar to that of the BxPC-3 cells significantly decreases HPAF-II migration (890 ± 67 square pixels; p = 0.0032) compared with the untransfected or GFP-vector control HPAF-II cells (1630 ± 183 and 1435 ± 235 square pixels, respectively).
Negative_regulation (decreases) of Gene_expression (expression) of cav-1 in BxPC-3
15) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.12 Pain Relevance 0
Previous studies demonstrated that activation of p42/p44 extracellular regulated kinase (Erk) decreased cav-1 protein levels in constitutively-active Ras transformed NIH3T3 cells [38].
Negative_regulation (decreased) of Gene_expression (levels) of cav-1 protein
16) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.16 Pain Relevance 0.03
The maxi-K channel-generated current in mouse fibroblasts is reduced when the channel's caveolin-binding motif is disrupted
Negative_regulation (disrupted) of Gene_expression (motif) of caveolin-binding in fibroblasts
17) Confidence 0.03 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0

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