INT163278

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.36
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CAV1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
Golgi apparatus (CAV1) endoplasmic reticulum (CAV1) intracellular (CAV1)
Anatomy Link Frequency
colon 2
HPAF-II 2
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 86.60 High High
cytokine 10 52.88 Quite High
Inflammation 10 52.48 Quite High
backache 16 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 6 100.00 Very High Very High Very High
Sarcoma 2 100.00 Very High Very High Very High
Cancer 152 99.66 Very High Very High Very High
Breast Cancer 4 98.64 Very High Very High Very High
Retinoblastoma 2 97.44 Very High Very High Very High
Aging 124 92.96 High High
Adenocarcinoma 104 90.08 High High
Malignant Neoplastic Disease 8 87.16 High High
Avian Sarcoma 1 81.28 Quite High
Stress 30 76.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study demonstrated that the increased expression of caveolin-1 seen in the degenerate NP positively correlated with gene expression for p16INK4a, suggesting that caveolin-1 expression is linked to the senescent phenotype observed in these cells.
Regulation (linked) of Gene_expression (expression) of caveolin-1
1) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.94 Pain Relevance 0
Moreover, we demonstrate a correlation between caveolin-1 and p16INK4a gene expression. p16INK4a is a cyclin-dependent kinase inhibitor that prevents retinoblastoma phosphorylation and arrests the cell cycle in the G0/G1 phase prior to entry into the synthesis phase [53,54].
Regulation (correlation) of Gene_expression (expression) of caveolin-1 associated with retinoblastoma
2) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.92 Pain Relevance 0.05
HCT-116 cells were exposed to 50 microM celecoxib, 25 microM lovastatin or a combination of both to assess their effect in modulating caveolin-1 expression and its down-stream signaling pathways.
Regulation (modulating) of Gene_expression (expression) of caveolin-1
3) Confidence 0.44 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.41 Pain Relevance 0.09
To determine if cav-1 expression affected RhoC activation, levels of GTP-bound RhoC was measured in the GFP-cav-1 and control HPAF-II cells (Figure 2C).
Regulation (affected) of Spec (determine) Gene_expression (expression) of cav-1 in HPAF-II
4) Confidence 0.43 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.37 Pain Relevance 0
For example, initial “gain of function” studies of Cav-1 ectopically expressed in breast cancer cells grown in vitro suggested that Cav-1 has tumor suppressor functions.83 Similar in vitro studies also suggested a tumor suppressor role for Cav-1 in colon cancer and sarcoma cell lines.84 Cav-1 expression is also reduced in primary human breast cancers, colon cancers, and sarcomas, consistent with the notion that Cav-1 functions as a tumor suppressor in these tumor types.84
Regulation (for) of Gene_expression (expression) of Cav-1 in colon associated with sarcoma, cancer, colon cancer and breast cancer
5) Confidence 0.42 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.43 Pain Relevance 0
Changes in cav-1 expression due to inhibitor treatment are also shown in Figure 5C.
Regulation (Changes) of Gene_expression (expression) of cav-1
6) Confidence 0.26 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.29 Pain Relevance 0

General Comments

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