INT163280

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.92
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 99.16 Very High Very High Very High
cINOD 1 66.64 Quite High
addiction 3 54.96 Quite High
Inflammation 1 45.64 Quite Low
Pain 4 44.96 Quite Low
agonist 27 5.00 Very Low Very Low Very Low
antagonist 13 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 101 99.20 Very High Very High Very High
Apoptosis 100 98.48 Very High Very High Very High
Reprotox - General 1 20 84.48 Quite High
Carcinoma In Situ 11 83.92 Quite High
Squamous Cell Carcinoma 1 83.44 Quite High
Cancer 140 78.68 Quite High
Carcinoma 61 78.08 Quite High
Colon Cancer 12 75.00 Quite High
Malignant Neoplastic Disease 22 70.64 Quite High
Stomach Cancer 2 67.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, frameshift mutations and stop codons lead to a truncated protein, which is not detected by antibodies and leads to negative immunohistochemistry [11, 18] After DNA damage, nuclear p53 accumulates and causes cell cycle arrest by inhibiting cyclin D1 phosphorylation of the Rb gene and thereby promoting apoptosis [9, 13].
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of cyclin D1 associated with apoptosis
1) Confidence 0.19 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.83 Pain Relevance 0
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Negative_regulation (decreased) of Phosphorylation (levels) of cyclin D1
2) Confidence 0.19 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
protein, but also with a decreased phosphorylation of ERK1/2 and decreased cyclin D1, and a paradoxical decrease of P21Cip1.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of cyclin D1
3) Confidence 0.17 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.59 Pain Relevance 0.03
protein, but also with a decreased phosphorylation of ERK1/2 and decreased cyclin D1, and a paradoxical decrease of P21Cip1.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of cyclin D1
4) Confidence 0.17 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.55 Pain Relevance 0.03
protein, but also with a decreased phosphorylation of ERK1/2 and decreased cyclin D1, and a paradoxical decrease of P21Cip1.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of cyclin D1
5) Confidence 0.17 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.54 Pain Relevance 0.03
Capsaicin-induced G1 arrest is correlated with the suppression of cyclin D1 levels, inhibition of cdk4 activity and Rb phosphorylation in endothelial and breast cancer cells [21], [22].
Negative_regulation (suppression) of Phosphorylation (phosphorylation) of cyclin D1 associated with qutenza and breast cancer
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 1.08 Pain Relevance 0.72

General Comments

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