INT163284

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.60
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 17 95.52 Very High Very High Very High
cINOD 3 66.64 Quite High
antagonist 2 46.00 Quite Low
Inflammation 22 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 44 97.64 Very High Very High Very High
Hypoxia 35 87.92 High High
Glioma 52 75.00 Quite High
Colon Cancer 8 75.00 Quite High
Cancer 134 67.24 Quite High
Adhesions 4 56.52 Quite High
Prostate Cancer 53 50.00 Quite Low
Apoptosis 62 32.80 Quite Low
Aging 8 31.92 Quite Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Negative_regulation (decreased) of Gene_expression (levels) of CDK2
1) Confidence 0.32 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
Expression of AR-regulated cell cycle genes, such as A-, B- and D-type cyclins, cyclin-dependent kinases (CDK1, CDK2, CDK4, CDK6) and cyclin-dependent kinase inhibitors (CDKN1B, CDKN2A, CDKN2B), was generally unaffected [40], [41], [42], [43], [44], [45].
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (Expression) of CDK2
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
Our treatment also reduced the expression of cyclin D1, cyclin D2, p-Rb and cyclin E while the expression of Cdk2 was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of Cdk2
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.25 Pain Relevance 0
As p27Kip1 is both an inhibitor and a substrate of cyclin E-Cdk2 complex [25], we analyzed the expression of these molecules using immunoblot analysis and found that the treatments decreased the expression of cyclin E whereas the expression of Cdk2 was unaffected (Fig. 3A).
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of Cdk2
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Hence, we analyzed the hepatic expression of cyclin E, CDK2, CDK4 and the cell cycle inhibitor p21cip1/waf1 in animals receiving continuous dietary DAB (HC) and in the HR animals.
Negative_regulation (inhibitor) of Spec (analyzed) Gene_expression (expression) of CDK2 associated with hepatocellular cancer
5) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.25 Pain Relevance 0.05
Hence, we analyzed the hepatic expression of cyclin E, CDK2, CDK4 and the cell cycle inhibitor p21cip1/waf1 in animals receiving continuous dietary DAB (HC) and in the HR animals.
Spec (analyzed) Negative_regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of CDK2 associated with hepatocellular cancer
6) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.24 Pain Relevance 0.05
When treated with JAKinase inhibitors, STAT3 phosphorylation and associated proliferation factors involving cell growth and CDK1, CDK2, Rex1, Nanog, and RUNX3 expression was decreased profoundly (Figure 3A and 3B, 3C).
Negative_regulation (decreased) of Gene_expression (expression) of CDK2
7) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.53 Pain Relevance 0

General Comments

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