INT163285

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 292 99.70 Very High Very High Very High
cINOD 1 66.64 Quite High
Central nervous system 10 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 4 75.00 Quite High
Cancer 1 67.24 Quite High
Neurodegenerative Disease 22 67.16 Quite High
Cytomegalovirus Infection 4 60.80 Quite High
Stress 27 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Cocaine Dependence 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Negative_regulation (decreased) of Phosphorylation (levels) of CDK2
1) Confidence 0.32 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
Western blotting showed that cocaine significantly decreased the phosphorylated forms of CDK2 and pRb (Figure 5A), indicating that cocaine-induced down-regulation of cyclin A results in a hypoactive state of the downstream cell cycle signaling pathway.


Negative_regulation (decreased) of Phosphorylation (phosphorylated) of CDK2 associated with cocaine
2) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.18 Pain Relevance 0.42

General Comments

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