INT163289

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.81
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 98.86 Very High Very High Very High
cINOD 1 66.08 Quite High
addiction 2 52.72 Quite High
Inflammation 35 45.04 Quite Low
Pain 2 44.36 Quite Low
metalloproteinase 4 14.08 Low Low
chemokine 19 10.80 Low Low
cytokine 17 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 45 99.20 Very High Very High Very High
Apoptosis 113 98.52 Very High Very High Very High
Cancer 300 94.76 High High
Stress 3 92.16 High High
Endometroid Carcinoma 33 91.68 High High
Gastrointestinal Stromal Tumor 5 87.36 High High
Leukemia 9 87.00 High High
Carcinoma In Situ 16 83.92 Quite High
Reprotox - General 1 18 83.88 Quite High
Squamous Cell Carcinoma 1 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, frameshift mutations and stop codons lead to a truncated protein, which is not detected by antibodies and leads to negative immunohistochemistry [11, 18] After DNA damage, nuclear p53 accumulates and causes cell cycle arrest by inhibiting cyclin D1 phosphorylation of the Rb gene and thereby promoting apoptosis [9, 13].
Phosphorylation (phosphorylation) of cyclin D1 associated with apoptosis
1) Confidence 0.36 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.82 Pain Relevance 0
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Phosphorylation (levels) of cyclin D1
2) Confidence 0.35 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
protein, but also with a decreased phosphorylation of ERK1/2 and decreased cyclin D1, and a paradoxical decrease of P21Cip1.
Phosphorylation (phosphorylation) of cyclin D1
3) Confidence 0.32 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.54 Pain Relevance 0.03
Capsaicin-induced G1 arrest is correlated with the suppression of cyclin D1 levels, inhibition of cdk4 activity and Rb phosphorylation in endothelial and breast cancer cells [21], [22].
Phosphorylation (phosphorylation) of cyclin D1 associated with qutenza and breast cancer
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 1.07 Pain Relevance 0.72
In response to DNA damage, nuclear P53 accumulates and causes cell cycle arrest by inhibiting Cyclin D1 phosphorylation of the Rb gene and thereby promotes apoptosis.
Phosphorylation (phosphorylation) of Cyclin D1 associated with apoptosis
5) Confidence 0.08 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 0.93 Pain Relevance 0
It is believed that phosphorylation of various proteins, such as cyclin E, cyclin D, p27, I?
Phosphorylation (phosphorylation) of cyclin D
6) Confidence 0.07 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.69 Pain Relevance 0
, which phosphorylates cyclin D1, triggering its nuclear export and degradation [84]–[86].
Phosphorylation (phosphorylates) of cyclin D1
7) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.43 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox