INT163290

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.57
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (MIF) cell proliferation (MIF) extracellular space (MIF)
extracellular region (MIF) cytoplasm (MIF)
Anatomy Link Frequency
coronary artery 1
macrophage 1
heart 1
MIF (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 24 99.60 Very High Very High Very High
Inflammation 197 99.48 Very High Very High Very High
anesthesia 12 99.42 Very High Very High Very High
cytokine 182 97.88 Very High Very High Very High
Inflammatory response 31 85.68 High High
Inflammatory marker 13 83.56 Quite High
spondylitis 6 79.76 Quite High
withdrawal 2 77.24 Quite High
Opioid 2 76.80 Quite High
Neuropathic pain 2 76.36 Quite High
Disease Link Frequency Relevance Heat
Multiple Organ Failure 40 99.80 Very High Very High Very High
Low Back Pain 30 99.60 Very High Very High Very High
INFLAMMATION 256 99.48 Very High Very High Very High
Malignant Neoplastic Disease 6 98.86 Very High Very High Very High
Disease 111 97.24 Very High Very High Very High
Lung Injury 3 96.72 Very High Very High Very High
Stress 13 96.24 Very High Very High Very High
Hypoglycemia 6 93.68 High High
Congenital Anomalies 3 93.08 High High
Hypoxia 23 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is no report of malignancy arising from the retained müllerian structures, and the absence of MIF does not appear to increase the relative risk of testicular malignancy.
MIF Neg (absence) Binding (absence) of associated with malignant neoplastic disease
1) Confidence 0.31 Published 2008 Journal Cases J Section Body Doc Link PMC2580765 Disease Relevance 0.80 Pain Relevance 0.03
Based on these results, MIF may be involved in the pathogenesis of the chronic inflammation in AS and, consequently, targeting MIF may be beneficial in preventing complications or in initiating early treatment of the disease.
MIF Binding (targeting) of associated with spinal inflammation, inflammation and disease
2) Confidence 0.28 Published 2010 Journal Mod Rheumatol Section Abstract Doc Link 19787418 Disease Relevance 1.70 Pain Relevance 0.84
Mediators such as macrophage migration inhibitory factor (MIF) and interleukin-10 (IL-10) are thought to be involved in several inflammatory conditions, including AS.
MIF Binding (macrophage) of in macrophage associated with spinal inflammation and inflammation
3) Confidence 0.28 Published 2010 Journal Mod Rheumatol Section Abstract Doc Link 19787418 Disease Relevance 1.41 Pain Relevance 0.84
Second, postoperative neurological dysfunction was was slightly and rarely associated with postoperative circulating levels of MIF.
MIF Binding (associated) of associated with anesthesia
4) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.43 Pain Relevance 0.23
First, a significant association between postoperative levels of MIF and pulmonary dysfunction has been reported previously in a study including patients without previous organ dysfunction who were subjected to elective coronary artery bypass surgery [14].
MIF Binding (association) of in coronary artery
5) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.52 Pain Relevance 0.23
The relative importance and interaction of HIF-1 and MIF in this context have not yet been examined, but these activities of TNF and MIF nevertheless stress that an understanding of malarial disease needs a broader vision than simple vascular occlusion.


MIF Binding (interaction) of associated with stress and disease
6) Confidence 0.13 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.53 Pain Relevance 0.18
Pressure-adjusted heart rate, the marker of circulatory dysfunction used in MODS, was not associated with circulating MIF.
MIF Binding (associated) of in heart associated with multiple organ failure
7) Confidence 0.12 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.47 Pain Relevance 0.06
The allosteric inhibition mechanism is further elucidated by X-ray crystallography based on the MIF/AV1013 binary and MIF/AV1013/HPP ternary complexes.
MIF Binding (complexes) of
8) Confidence 0.07 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20534506 Disease Relevance 0.35 Pain Relevance 0.19
The allosteric inhibition mechanism is further elucidated by X-ray crystallography based on the MIF/AV1013 binary and MIF/AV1013/HPP ternary complexes.
MIF Binding (binary) of
9) Confidence 0.07 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20534506 Disease Relevance 0.35 Pain Relevance 0.19

General Comments

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