INT163329

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 7.34
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRL) extracellular region (GHRL) cytoplasm (GHRL)
Anatomy Link Frequency
muscles 2
plasma 1
GHRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 20 99.92 Very High Very High Very High
depression 9 98.36 Very High Very High Very High
Inflammation 30 64.68 Quite High
abdominal pain 1 55.12 Quite High
palliative 30 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anorexia 21 100.00 Very High Very High Very High
Fatigue 24 99.96 Very High Very High Very High
Pain 20 99.92 Very High Very High Very High
Obesity 35 99.84 Very High Very High Very High
Constipation 12 99.68 Very High Very High Very High
Cognitive Disorder 9 99.52 Very High Very High Very High
Vomiting 24 99.12 Very High Very High Very High
Syndrome 1 98.98 Very High Very High Very High
Xerostomia 12 98.80 Very High Very High Very High
Celiac Disease 7 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with shortbowel syndrome, reduction in the intestinal tissue resulted in a decrease in the circulating ghrelin levels.
Negative_regulation (decrease) of ghrelin associated with syndrome
1) Confidence 0.58 Published 2010 Journal J. Endocrinol. Invest. Section Abstract Doc Link 19794298 Disease Relevance 0.94 Pain Relevance 0.06
For example, nausea, constipation and vomiting accounted for 90% of the variance in the GI/pain/cognitive function symptom cluster, while lack of appetite explained only 0.8% of the variance (Table 6).
Negative_regulation (lack) of appetite associated with pain, cognitive disorder, constipation, vomiting and anorexia
2) Confidence 0.12 Published 2003 Journal BMC Cancer Section Body Doc Link PMC317311 Disease Relevance 1.43 Pain Relevance 0.22
The two highest ranked (most prevalent) symptoms were lack of energy and tiredness, followed by lack of appetite and pain while the four lowest ranked (least prevalent) symptoms were numbness or tingling of the hands or feet, sore muscles, dizziness and heartburn.
Negative_regulation (lack) of appetite in muscles associated with pain, hypesthesia, dizziness, gastroesophageal reflux disease, anorexia and fatigue
3) Confidence 0.12 Published 2003 Journal BMC Cancer Section Body Doc Link PMC317311 Disease Relevance 1.73 Pain Relevance 0.19
The symptoms included in this list were: Lack of energy, tiredness, lack of appetite, pain, constipation, nausea, dry mouth, depression, anxiety, difficulty sleeping, tenseness, vomiting, shortness of breath, lack of sexual interest, irritability, nervousness, heartburn, dizziness, sore muscles, and numbness or tingling of the hands or feet.


Negative_regulation (lack) of appetite in muscles associated with pain, constipation, depression, vomiting, gastroesophageal reflux disease, xerostomia, anorexia, hypesthesia, dizziness, fatigue, anxiety and dyspnea
4) Confidence 0.12 Published 2003 Journal BMC Cancer Section Body Doc Link PMC317311 Disease Relevance 1.64 Pain Relevance 0.15
A recent study has linked obestatin to obesity in humans, showing that fasting plasma obestatin was significantly suppressed in obese subjects (15, 16) and increased as weight was lost.
Negative_regulation (suppressed) of obestatin in plasma associated with obesity
5) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.87 Pain Relevance 0.03
Vicennati et al. (30) study showed that in the presence of obesity, women had a decreased ghrelin/obestatin ratio.
Negative_regulation (decreased) of obestatin associated with obesity
6) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.72 Pain Relevance 0

General Comments

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