INT163358

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 34
Disease Relevance 12.47
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppargc1a) RNA binding (Ppargc1a) mitochondrion organization (Ppargc1a)
nucleus (Ppargc1a) DNA binding (Ppargc1a) transcription factor binding (Ppargc1a)
Anatomy Link Frequency
skeletal muscle 2
Motor nerve 1
liver 1
muscle 1
Ppargc1a (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 902 99.60 Very High Very High Very High
qutenza 9 96.48 Very High Very High Very High
Acupuncture 110 94.72 High High
adenocard 2 89.04 High High
cOX1 11 87.40 High High
tolerance 163 84.72 Quite High
Inflammatory response 5 84.16 Quite High
Osteoarthritis 11 79.52 Quite High
Fibrositis 11 78.52 Quite High
Pain 11 77.96 Quite High
Disease Link Frequency Relevance Heat
Obesity 521 99.70 Very High Very High Very High
Targeted Disruption 134 99.68 Very High Very High Very High
Diabetes Mellitus 214 99.52 Very High Very High Very High
Syndrome 2 99.36 Very High Very High Very High
Insulin Resistance 415 99.26 Very High Very High Very High
Congenital Anomalies 76 93.28 High High
Sprains And Strains 35 92.16 High High
Adhesions 13 91.92 High High
Stress 96 91.36 High High
Cancer 65 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
had 3.3-, 3.8- and 3.6-fold (p<0.001, 0.01 and 0.001, respectively) increases in Pgc-1?
Positive_regulation (increases) of Pgc
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0
This is somewhat supported by our current data of upregulated PGC-1?
Positive_regulation (upregulated) of PGC
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.25 Pain Relevance 0
, is capable of blocking endurance exercise-induced transcriptional activation of the Pgc-1?
Positive_regulation (activation) of Pgc
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0
In the present study, we found that ROS induced phosphorylation of CREB and activation of PGC-1?
Positive_regulation (activation) of PGC
4) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.08 Pain Relevance 0
Next, to investigate whether ROS induces the phosphorylation of CREB and, hence, results in activation of PGC1?
Positive_regulation (activation) of PGC
5) Confidence 0.67 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.07 Pain Relevance 0
Specifically, low-frequency EA improved insulin sensitivity in a mouse model of genetic insulin resistance and diabetes, at least in part, via stimulation of SIRT1/PGC-1?
Positive_regulation (stimulation) of PGC-1 associated with diabetes mellitus, insulin resistance and electroacupuncture
6) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.69 Pain Relevance 0.31
Collectively, these studies support the possibility that EA improves insulin sensitivity, at least partially, because of increasing SIRT1/PGC-1?
Positive_regulation (increasing) of PGC-1 associated with electroacupuncture
7) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.44 Pain Relevance 0.15
It is possible that elevated PGC-1?
Positive_regulation (elevated) of PGC-1
8) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.52 Pain Relevance 0.17
Meanwhile, electric stimulation such as exercise induces muscle contraction, which has been observed to activate SIRT1/PGC-1?
Positive_regulation (activate) of PGC-1 in muscle
9) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.71 Pain Relevance 0.37
is a coactivator for NRF1 expression [24], discrepancy between induced PGC-1?
Positive_regulation (induced) of PGC-1
10) Confidence 0.55 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.39 Pain Relevance 0.19
Increased PGC-1?
Positive_regulation (Increased) of PGC-1
11) Confidence 0.55 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.85 Pain Relevance 0.13
coactivator, PGC-1?
Positive_regulation (coactivator) of PGC
12) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.44 Pain Relevance 0.03
While Foxo1 is known as a positive regulator of PGC-1?
Positive_regulation (regulator) of PGC
13) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.06 Pain Relevance 0.03
Motor nerve stimulation-induced Pgc-1?
Positive_regulation (induced) of Pgc in Motor nerve
14) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.06 Pain Relevance 0
The inhibition of hepatic insulin resistance was accompanied by attenuation of phosphorylation of cAMP-responsive element-binding protein (CREB), which is a main regulator of PGC-1?
Positive_regulation (regulator) of PGC associated with insulin resistance
15) Confidence 0.49 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494675 Disease Relevance 0.60 Pain Relevance 0
Our results also suggest a broader role for inducible transcriptional coactivators such as PGC-1?
Positive_regulation (inducible) of PGC-1
16) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.09 Pain Relevance 0
Our results also suggest a broader role for inducible transcriptional coactivators such as PGC-1?
Positive_regulation (role) of PGC-1
17) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.09 Pain Relevance 0
The DBKO mice showed an up-regulation of Pgc-1 ?
Positive_regulation (up-regulation) of Pgc associated with targeted disruption
18) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.69 Pain Relevance 0
The DBKO mice showed an up-regulation of Pgc-1 ?
Positive_regulation (up-regulation) of Pgc-1 associated with targeted disruption
19) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.69 Pain Relevance 0
At the same time, the mRNA/protein of adiponectin in the adipose tissue and PPARalpha/PGC-1alpha mRNA in the liver increased.
Positive_regulation (increased) of PGC-1alpha in liver associated with obesity
20) Confidence 0.45 Published 2010 Journal Obesity (Silver Spring) Section Abstract Doc Link 19798065 Disease Relevance 1.54 Pain Relevance 0.58

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