INT163359

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.34
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RFC1) nucleus (RFC1) intracellular (RFC1)
Anatomy Link Frequency
cardiomyocyte 1
muscles 1
ovary 1
RFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 259 100.00 Very High Very High Very High
bradykinin 3 99.64 Very High Very High Very High
Angina 13 98.24 Very High Very High Very High
Inflammation 41 97.84 Very High Very High Very High
Opioid 8 96.72 Very High Very High Very High
agonist 359 96.24 Very High Very High Very High
Duloxetine 1 95.12 Very High Very High Very High
abatacept 1 92.96 High High
Potency 107 88.52 High High
Gabapentin 1 88.20 High High
Disease Link Frequency Relevance Heat
Hypoxia 14 99.60 Very High Very High Very High
Ventricular Tachycardia 1 99.34 Very High Very High Very High
Arrhythmia Under Development 1 98.36 Very High Very High Very High
Myocardial Infarction 28 98.26 Very High Very High Very High
Cv General 3 Under Development 12 98.24 Very High Very High Very High
INFLAMMATION 46 97.84 Very High Very High Very High
Cancer 127 97.44 Very High Very High Very High
Solid Tumor 3 93.80 High High
Apnoea 1 87.68 High High
Reperfusion Injury 8 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gateways to clinical trials.

[90Y-DOTA-Tyr3]octreotate, Abatacept, ABT-888, ACE-011, Adefovir dipivoxil, Alosetron hydrochloride, Aminolevulinic acid methyl ester, Amlodipine, Apaziquone, Aripiprazole, AS-101, Atomoxetine hydrochloride, Atrasentan, Azacitidine; Bevacizumab, Biphasic insulin aspart, Bortezomib, Bosentan, Brivanib alaninate; CERE-120, Cetuximab, Ciclesonide, Cinacalcet hydrochloride, Combretastatin A-1 phosphate, Conatumumab, CT-322; Dabigatran etexilate, Darunavir, Deforolimus, Desloratadine, Doripenem, Doxorubicin eluting beads, Duloxetine hydrochloride, Dutasteride; Escitalopram oxalate, Eszopiclone, Etravirine, Exenatide, Ezetimibe, Ezetimibe/simvastatin; Fluticasone furoate, Fondaparinux sodium; Gabapentin enacarbil, Ghrelin (human), Golimumab; IC-51, IDM-2, JX-594; Lidocaine/prilocaine, Liraglutide, Lopinavir, Lopinavir/ritonavir, Lumiracoxib; Men ACWY, MxdnG1; Naproxcinod; OBP-301, Omalizumab; Paclitaxel nanoparticles, Pasireotide, Pazopanib hydrochloride, Pegaptanib octasodium, Peginterferon alfa-2a, Pegvisomant, Pemetrexed disodium, Pimecrolimus, Prasterone, Pregabalin; Raclopride, Ranelic acid distrontium salt, Ranibizumab, RB-006, Recombinant human relaxin H2, REG1, Regadenoson, Reximmune-C, Rilonacept; Saxagliptin, SCH-697243, Solifenacin succinate, Sorafenib; Tadalafil, Tapentadol hydrochloride, Tenofovir disoproxil fumarate, Tenofovir disoproxil fumarate/emtricitabine, Tipifarnib, Tolvaptan; Vardenafil hydrochloride hydrate, Vicriviroc, Volociximab, Vorinostat; WB-1001; Yttrium 90 (90Y) ibritumomab tiuxetan.

Gene_expression (phosphate) of A-1 associated with pregabalin, abatacept, lidocaine, gabapentin and duloxetine
1) Confidence 0.65 Published 2009 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 19798455 Disease Relevance 0 Pain Relevance 0.39
Activation of specific receptors on the cardiomyocyte cell membrane such as adenosine A1 and A3, bradykinin B2, ?
Gene_expression (adenosine) of A1 in cardiomyocyte associated with adenocard and bradykinin
2) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.07 Pain Relevance 0.30
Chinese hamster ovary (CHO) cells stably expressing A1 or A3 AR were maintained at 37°C with 5% CO2 in a 1:1 mixture of Dulbecco's modified Eagle's medium (DMEM) and Ham's F12 medium, supplemented with 10% fetal bovine serum (FBS), 100 units/ml penicillin, 100 ?
Gene_expression (expressing) of A1 in ovary
3) Confidence 0.11 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.26
The preparation of membranes from CHO cells stably expressing human A1 or A3 AR was as previously described [18]. [35S]GTP?
Gene_expression (expressing) of A1
4) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.14
any of four subtypes of adenosine-selective, G-protein-coupled receptors: A1,
Gene_expression (selective) of A1 associated with adenocard
5) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.24 Pain Relevance 0.34
Under physiological conditions, intracellular adenosine reaches a concentration of 100 nM and thus is able to interact only with the high-affinity A1 and A2A AR subtypes.
Gene_expression (subtypes) of A1 associated with adenocard
6) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.25 Pain Relevance 0.50
299 nM), although the selectivity profile was not so satisfactory (Ki values at A1, A2A, A3 ARs of 148, 45, 232 nM, respectively).
Gene_expression (values) of A1
7) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.07 Pain Relevance 0.38
BAY-60–6583, characterised with CHO cells expressing recombinant human A1, A2A or A2B ARs, showed EC50 values for receptor activation >10,000 nM for both A1 and A2A AR and 3 nM for A2B AR subtypes.
Gene_expression (expressing) of A1
8) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.83 Pain Relevance 0.26
In a retrospective comparison between 24 hour HRV analysis using several techniques in patients post-myocardial infarction with or without inducible ventricular tachyarrhythmia [97], a decrease in the scaling exponent a1 was the strongest predictor of risk for ventricular arrhythmia.
Gene_expression (exponent) of a1 associated with ventricular tachycardia, arrhythmia under development and myocardial infarction
9) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC1065053 Disease Relevance 0.75 Pain Relevance 0.08
In all cases (Figure 9 – SEMG and MMG, both muscles) the average slope (a1) of the MF evolution is negative.
Neg (negative) Gene_expression (negative) of a1 in muscles
10) Confidence 0.03 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC443861 Disease Relevance 0.14 Pain Relevance 0

General Comments

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