INT163361

Context Info Confidence 0.42 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 6.60 Pain Relevance 0.43

cytosol (SAMSN1) nucleus (SAMSN1) cytoplasm (SAMSN1)

Anatomy Link Frequency body 1 SAMSN1 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 67 98.86 Inflammation 13 98.60 cINOD 2 70.20 alcohol 27 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Nash(non-alcoholic Steatohepatitis) 281 100.00 Disorder Of Lipid Metabolism 15 100.00 Body Weight 1 99.48 Fibrosis 67 98.86 INFLAMMATION 14 98.60 Hepatitis 63 98.48 Metabolic Syndrome 8 96.74 Insulin Resistance 14 96.34 Cirrhosis 15 91.76 Fatty Liver 88 90.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Studies have identified community prevalence, clinical outcomes, association with insulin resistance, metabolic syndrome and hypoadiponectinemia, developed and explored animal models for mechanisms of inflammation and fibrosis, conceptualized etiopathogenesis, and demonstrated that NASH can be reversed by lowering body weight and increasing physical activity.

Negative_regulation (reversed) of NASH in body associated with fibrosis, nash(non-alcoholic steatohepatitis), body weight, inflammation, metabolic syndrome and insulin resistance

1) Confidence 0.42 Published 2009 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 19799688 Disease Relevance 2.14 Pain Relevance 0.24

However the decrease of apolipoprotein A1 in NASH was much lower than in patients with ASH.

Negative_regulation (decrease) of NASH associated with nash(non-alcoholic steatohepatitis), hepatitis and disorder of lipid metabolism

2) Confidence 0.41 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.90 Pain Relevance 0.03

Diagnostic values of NT for predicting borderline NASH and NASH in different groups, are given in Table 4 for the concordance with biopsy results, and in Table 5 for sensitivity, specificity and predictive values.

Negative_regulation (predicting) of NASH associated with nash(non-alcoholic steatohepatitis)

3) Confidence 0.35 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.28 Pain Relevance 0.08

Diagnostic values of NT for predicting borderline NASH and NASH in different groups, are given in Table 4 for the concordance with biopsy results, and in Table 5 for sensitivity, specificity and predictive values.

Negative_regulation (predicting) of NASH associated with nash(non-alcoholic steatohepatitis)

4) Confidence 0.35 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.28 Pain Relevance 0.08

General Comments

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