INT163366

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.72
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (Foxp3) nucleus (Foxp3) intracellular (Foxp3)
embryo development (Foxp3) molecular_function (Foxp3) cellular_component (Foxp3)
Anatomy Link Frequency
lamina 1
Foxp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 93 98.16 Very High Very High Very High
Inflammation 30 97.88 Very High Very High Very High
cytokine 18 50.00 Quite Low
pain pelvic 2 50.00 Quite Low
Prostatitis 2 50.00 Quite Low
abdominal pain 2 48.32 Quite Low
chemokine 6 5.00 Very Low Very Low Very Low
nud 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

92 98.16 Very High Very High Very High
INFLAMMATION 31 97.88 Very High Very High Very High
Chronic Pelvic Pain Syndrome 2 72.64 Quite High
Reprotox - General 1 2 50.00 Quite Low
Abdominal Pain 2 48.32 Quite Low
Hypersensitivity 1 23.20 Low Low
Stress 11 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 9 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Microscopic Colitis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chadwick et al,11 reported increased numbers of T cells expressing CD25+ in the lamina propria of the colon that could be related with the low immune activation in the bowel.50 Recently, it has been hypothesized that CD4+ CD25+ T regulatory (Treg) cells are reduced in numbers and in their functional capabilities, producing an inadequate suppression of intestinal inflammatory activity.51 However, research data from Holmén et al51 did not find a significant difference in the mRNA expression of the FoxP3 - a specific marker of Treg cells -, between IBS patients and healthy controls, or in the suppressive activity of the peripheral CD4+ CD25+ cells from patients and controls.
Transcription (expression) of FoxP3 in lamina associated with inflammation and spastic colon
1) Confidence 0.35 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.24 Pain Relevance 0.53
RESULTS: The FOXP3 gene mRNA level in CP/CPPS patients was significantly lower than that in controls.
Transcription (level) of FOXP3
2) Confidence 0.11 Published 2010 Journal Urology Section Body Doc Link 19800664 Disease Relevance 0.07 Pain Relevance 0

General Comments

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