INT163381

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
hippocampus 1
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 98.70 Very High Very High Very High
Hippocampus 6 97.32 Very High Very High Very High
fluoxetine 8 96.20 Very High Very High Very High
Morphine 5 94.20 High High
opioid receptor 3 92.56 High High
Neuropeptide 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 7 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simultaneously, hippocampal neurogenesis was determined by assessing cell proliferation, survival and differentiation. mRNA and protein expression of Notch1 signaling components (including Jag1, NICD, Hes1 and Hes5) in the hippocampus increased after fluoxetine administration, accompanied by cell proliferation and survival.
Transcription (expression) of Notch1 in hippocampus associated with hippocampus, neurodegenerative disease and fluoxetine
1) Confidence 0.69 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801843 Disease Relevance 0.41 Pain Relevance 0.87
The differential effects of agonists on NeuroD activity were further confirmed by measuring the mRNA levels of four NeuroD downstream targets: doublecortin, Notch1, neurogenic differentiation 4, and Roundabout 1.
Transcription (levels) of Notch1 associated with agonist
2) Confidence 0.08 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554861 Disease Relevance 0 Pain Relevance 0.66

General Comments

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