INT163390

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.42
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Crp) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
liver 2
smooth muscle cell 2
Il6 (Rattus norvegicus)
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Inflammation 29 99.00 Very High Very High Very High
alcohol 1 97.68 Very High Very High Very High
rheumatoid arthritis 32 89.68 High High
bradykinin 1 83.92 Quite High
Neuropeptide 1 80.80 Quite High
Inflammatory marker 2 77.32 Quite High
Pain 2 25.00 Low Low
cINOD 7 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 99.00 Very High Very High Very High
Obesity 9 96.32 Very High Very High Very High
Infection 10 96.08 Very High Very High Very High
Pneumonia 51 95.96 Very High Very High Very High
Birth Weight 1 94.32 High High
Disease 37 92.68 High High
Arthritis 3 92.36 High High
Rheumatoid Arthritis 32 89.68 High High
Hyperplasia 17 84.16 Quite High
Death 3 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo, IL-6 is a strong inducer of liver C-reactive protein (CRP) production which is able to stimulate endothelial and smooth muscle cell proliferation providing a pathway for Cpn to aggravate vein graft failure [24].
IL-6 Positive_regulation (inducer) of Gene_expression (production) of CRP in smooth muscle cell associated with pneumonia
1) Confidence 0.03 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2222630 Disease Relevance 1.26 Pain Relevance 0.11
and interleukin-6, thereby increasing CRP levels through upregulation of hepatic synthesis [27].
interleukin-6 Positive_regulation (increasing) of Gene_expression (levels) of CRP
2) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483462 Disease Relevance 1.57 Pain Relevance 0.34
At the molecular level, production of CRP is induced by proinflammatory cytokines IL-1, IL-6, and IL-17 in the liver, although extra hepatic production most likely contributes to systemic concentrations.
IL-6 Spec (likely) Positive_regulation (induced) of Gene_expression (production) of CRP in liver associated with cytokine
3) Confidence 0.01 Published 2009 Journal Adv Clin Chem Section Abstract Doc Link 19803417 Disease Relevance 0.60 Pain Relevance 0.51

General Comments

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