INT1634

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Context Info
Confidence 0.75
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 14.98
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) extracellular region (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
plasma 7
blood 2
liver 1
cardiovascular system 1
nephron 1
Gcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
Somatostatin 8 99.92 Very High Very High Very High
agonist 5 99.44 Very High Very High Very High
Enkephalin 3 99.24 Very High Very High Very High
anesthesia 14 98.84 Very High Very High Very High
Morphine 11 98.80 Very High Very High Very High
Dopamine 2 97.92 Very High Very High Very High
Clonidine 8 97.84 Very High Very High Very High
tolerance 25 96.60 Very High Very High Very High
Serotonin 1 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Cancer 95 99.88 Very High Very High Very High
Stress 29 99.64 Very High Very High Very High
Appetite Loss 529 99.48 Very High Very High Very High
Hypertension 11 98.32 Very High Very High Very High
Sprains And Strains 1 97.52 Very High Very High Very High
Impaired Glucose Tolerance 34 96.92 Very High Very High Very High
Diabetes Insipidus 1 96.72 Very High Very High Very High
Pheochromocytoma 10 96.56 Very High Very High Very High
Fibrosis 11 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The glucagon-producing cells decreased in number.
Gene_expression (producing) of glucagon
1) Confidence 0.75 Published 1999 Journal Ultrastruct Pathol Section Abstract Doc Link 10445284 Disease Relevance 1.01 Pain Relevance 0.20
Plasma glucagon levels were similar in sham-operated and portal hypertensive rats: glucagon, sham vs PV stenosed: 110.7 +/- 17.1 pmol/liter vs 140.6 +/- 23.3 pmol/liter (NS).
Gene_expression (levels) of glucagon in Plasma associated with hypertension
2) Confidence 0.68 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7648985 Disease Relevance 0.85 Pain Relevance 0.25
Evidence is given for the presence of material resembling corticotropin-like intermediate peptide in arcuate and periarcuate neurons, projecting to various hypothalamic nuclei, limbic areas and the thalamus. beta-Endorphin and glucagon decrease dopamine turnover in the median eminence, while secretin increases dopamine turnover and vasoactive intestinal polypeptide (VIP) has no effect. beta-Endorphin, VIP, secretin, and glucagon all produce discrete changes in norepinephrine turnover in various hypothalamic nuclei.
Gene_expression (produce) of glucagon in median eminence associated with dopamine and thalamus
3) Confidence 0.65 Published 1979 Journal Fed. Proc. Section Abstract Doc Link 222624 Disease Relevance 0 Pain Relevance 0.34
No 3.5K glucagon was detected in any of the extracts.
Gene_expression (detected) of glucagon
4) Confidence 0.61 Published 1988 Journal Endocrinology Section Abstract Doc Link 2454801 Disease Relevance 0 Pain Relevance 0.08
Furthermore, plasma levels of glucagon and the related peptide VIP were not significantly influenced by anesthesia or surgical stress, and levels remained similar under all conditions in sham-operated and PV-stenosed animals.
Gene_expression (levels) of glucagon in plasma associated with stress and anesthesia
5) Confidence 0.60 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7648985 Disease Relevance 0.83 Pain Relevance 0.26
Glucose, insulin and glucagon levels were significantly higher in morphine treated than in control rats.
Gene_expression (levels) of glucagon associated with morphine
6) Confidence 0.58 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102765 Disease Relevance 0 Pain Relevance 0.96
The plasma insulin concentration was consistently higher in SX rats than in C rats, and was significantly decreased by glucagon antibodies in SX as well as in C rats.
Gene_expression (decreased) of glucagon in plasma
7) Confidence 0.58 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7021387 Disease Relevance 0.08 Pain Relevance 0.06
The glucagon test alone was highly specific but not sensitive, and the clonidine test was highly sensitive but less specific.
Gene_expression (test) of glucagon associated with clonidine
8) Confidence 0.58 Published 1991 Journal Hypertension Section Abstract Doc Link 2045133 Disease Relevance 0.65 Pain Relevance 0.39
The acute hyperglycemic effect of KX in fed rats was associated with decreased plasma levels of insulin, adrenocorticotropic hormone (ACTH), and corticosterone and increased levels of glucagon and growth hormone (GH).
Gene_expression (levels) of glucagon in plasma
9) Confidence 0.54 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16246906 Disease Relevance 0.48 Pain Relevance 0.31
It is evident from elevated levels of ACTH, hydrocortisone, leuenkephaline, glucagon and gastrin.
Gene_expression (levels) of glucagon
10) Confidence 0.52 Published 1991 Journal Vopr Kurortol Fizioter Lech Fiz Kult Section Abstract Doc Link 1838221 Disease Relevance 0.10 Pain Relevance 0.08
The fasted rats given Pentobarbital had unchanged blood glucose and plasma insulin and a non-significant depression of glucagon.
Gene_expression (depression) of glucagon in blood associated with depression
11) Confidence 0.52 Published 1994 Journal Lab. Anim. Section Abstract Doc Link 7967463 Disease Relevance 0.17 Pain Relevance 0.09
-cells and glucagon production 40, 41.
Gene_expression (production) of glucagon
12) Confidence 0.43 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 1.09 Pain Relevance 0
All tumors were negative for insulin, glucagon, gastrin, vasoactive intestinal polypeptide, somatostatin, adrenocorticotropic hormone, calcitonin, serotonin, pancreatic polypeptide, and rat atrial peptide.
Neg (negative) Gene_expression (negative) of glucagon associated with cancer, somatostatin and serotonin
13) Confidence 0.39 Published 1985 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 3907377 Disease Relevance 1.28 Pain Relevance 0.23
At the time intervals sampled, radioimmunoassayable plasma levels of growth hormone, glucagon, and insulin were not significantly changed after injection of NT into normal rats.
Gene_expression (levels) of glucagon in plasma
14) Confidence 0.38 Published 1976 Journal Endocrinology Section Abstract Doc Link 826391 Disease Relevance 0.31 Pain Relevance 0.09
Like wise plasma glucagon levels were not affected by early malnutrition (MGL) or by late malnutrition (MA) in the acute test or after balance rehabilitation (fig. 5 A, B, C and G, H).
Gene_expression (levels) of glucagon in plasma associated with appetite loss
15) Confidence 0.37 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 1.77 Pain Relevance 0
We determine plasma concentrations of insulin, glucagon, triacylglycerols (TAG), free fatty acids (FFA), and liver glycogen after a Glucose Tolerance Test (GTT).
Gene_expression (concentrations) of glucagon in liver associated with tolerance and impaired glucose tolerance
16) Confidence 0.37 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2586678 Disease Relevance 0.90 Pain Relevance 0.12
The most remarkable finding in this study is the severe alterations observed in the MPW rats in blood glucose, insulin and glucagon levels.
Gene_expression (levels) of glucagon in blood associated with appetite loss
17) Confidence 0.37 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 0.92 Pain Relevance 0
Future studies from us will estimate the effects of this DPP-IV inhibitor on the enzyme activity/expression, as well as on levels of GLP-1 and glucagon, in order to have a more detailed picture of how the incretins pathway is affected and its relative contribution for the effects of sitagliptin here reported.
Gene_expression (levels) of glucagon
18) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 0.88 Pain Relevance 0
Under physiological conditions, the pancreas scarcely influences the function of the cardiovascular system, although the hormones produced in the healthy pancreas (insulin, glucagon and somatostatin) affect the myocardial contractility in pharmacological doses.
Gene_expression (produced) of glucagon in cardiovascular system associated with somatostatin
19) Confidence 0.32 Published 1997 Journal Orv Hetil Section Abstract Doc Link 9289688 Disease Relevance 0.91 Pain Relevance 0.16
Increased glucagon levels can lead to anorexia, as well as increased hepatic gluconeogenesis and utilisation of gluconeogenic amino acids at the expense of protein synthesis, leading to a negative energy balance [25].
Gene_expression (levels) of glucagon associated with appetite loss
20) Confidence 0.25 Published 2002 Journal BMC Cancer Section Body Doc Link PMC111198 Disease Relevance 0.91 Pain Relevance 0

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