INT163405

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 9.39
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
epithelial cells 2
AR42J 2
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 8 99.84 Very High Very High Very High
Nicotine 75 99.80 Very High Very High Very High
cocaine 292 99.56 Very High Very High Very High
antagonist 29 99.36 Very High Very High Very High
Arthritis 23 90.40 High High
Inflammation 275 88.80 High High
rheumatoid arthritis 72 86.96 High High
Osteoarthritis 69 83.56 Quite High
cytokine 163 82.56 Quite High
Substantia nigra 4 82.08 Quite High
Disease Link Frequency Relevance Heat
Stress 257 99.98 Very High Very High Very High
Hypoxia 60 99.80 Very High Very High Very High
Parkinson's Disease 17 99.80 Very High Very High Very High
Apoptosis 443 99.74 Very High Very High Very High
Death 193 98.44 Very High Very High Very High
Neurodegenerative Disease 74 98.32 Very High Very High Very High
Neurological Disease 11 97.60 Very High Very High Very High
Toxicity 72 97.08 Very High Very High Very High
Disease 228 96.80 Very High Very High Very High
Hyperplasia 7 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this context, two concepts should be underlined: first, the ER is a unique oxygen folding environment in which disulfide bonds can be formed – unfortunately, even in normal conditions protein folding can lead to ROS generation, likely as by-products of protein oxidation occurring in the ER; and second, oxidative stress, whatever the source, can affect ER and activate UPR, the latter initially operating as an adaptative mechanism to preserve cell function and favour cell survival.
Positive_regulation (lead) of ROS Spec (likely) Binding (generation) of associated with stress
1) Confidence 0.27 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.43 Pain Relevance 0
Reactive oxygen species formation was assessed by a spectrofluorometry method and garlic extract was shown to be as effective as NAC in decreasing ROS formation induced by acetaminophen.
Positive_regulation (induced) of ROS Binding (formation) of associated with paracetamol
2) Confidence 0.25 Published 2009 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19806806 Disease Relevance 0.28 Pain Relevance 0.51
During hypoxia, reduced ROS formation serves to activate HIF-1?
Positive_regulation (activate) of ROS Binding (formation) of associated with hypoxia
3) Confidence 0.23 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.82 Pain Relevance 0.15
Using the DCF assay, ultrafine particles were investigated for their stimulation of ROS formation during in vitro exposures of cultured human lung epithelial cells.
Spec (investigated) Positive_regulation (stimulation) of ROS Binding (formation) of in epithelial cells
4) Confidence 0.22 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0 Pain Relevance 0
L-PGDS knockdown inhibits shear-induced ROS formation, suggesting the involvement of PGD2 and/or its metabolite 15d-PGJ2 in this process.
Positive_regulation (induced) of ROS Binding (formation) of
5) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.14 Pain Relevance 0.33
Interestingly, rosiglitazone induced the generation of ROS, whereas cotreatment
Positive_regulation (induced) of ROS Binding (generation) of
6) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.09 Pain Relevance 0.06
To explore the possibility that NCTD induced intracellular ROS in antiproliferation, the HepG2 cells were pretreated with NAC (10 mM) 2 h before treatment with NCTD, followed by NCTD (5,10,20,40 ?
Positive_regulation (induced) of ROS Binding (intracellular) of
7) Confidence 0.12 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.18 Pain Relevance 0
Although fMLF provokes NADPH oxidase activation, exposure to PAF does not induce ROS generation.
Neg (not) Positive_regulation (induce) of ROS Neg (not) Binding (generation) of
8) Confidence 0.11 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
M caused ROS generation even earlier, with a significant increase 15 min after the exposure.
Positive_regulation (caused) of ROS Binding (generation) of
9) Confidence 0.11 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.42 Pain Relevance 0.55
Treatment of PMN cells with MTB and CW before exposing the cells to oxidative stress and resulting ROS formation showed that both MTB and CW inhibited the H2O2-induced ROS formation (Figure 1B).
Positive_regulation (induced) of ROS Binding (formation) of associated with stress
10) Confidence 0.08 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.31 Pain Relevance 0.10
TMP also exhibited a calcium antagonist role in vascular tissues [11]; functioned as a ROS scavenger to deactivate cytotoxic ROS such as superoxide anion (O2?)
Positive_regulation (functioned) of ROS Binding (scavenger) of associated with antagonist
11) Confidence 0.08 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723671 Disease Relevance 0.49 Pain Relevance 0.27
Both MTB and CW inhibited spontaneous and oxidative stress-induced ROS formation in human PMN cells and increased the phagocytic activity of PMN cells in response to bacteria-like carboxylated fluorospheres.
Positive_regulation (induced) of ROS Binding (formation) of associated with stress
12) Confidence 0.08 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC2858026 Disease Relevance 0.54 Pain Relevance 0.14
Both MTB and CW inhibited spontaneous and H2O2-induced ROS formation.
Positive_regulation (induced) of ROS Binding (formation) of
13) Confidence 0.08 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.20 Pain Relevance 0.09
Since both paraquat and diquat can generate the formation of ROS, these compounds may well be involved in neurodegenerative diseases other than PD, such as Alzheimer's disease, but little evidence is available to evaluate this potential.
Positive_regulation (generate) of ROS Binding (formation) of associated with disease and neurodegenerative disease
14) Confidence 0.06 Published 2008 Journal Environ Health Section Body Doc Link PMC2577708 Disease Relevance 1.22 Pain Relevance 0.11
can induce apoptosis directly by increasing generation of ROS and mitochondrial dysfunction.
Positive_regulation (increasing) of ROS Binding (generation) of associated with parkinson's disease and apoptosis
15) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.39 Pain Relevance 0.04
Upon binding to RAGE and activating intracellular ROS formation, S100B activates the PI 3-kinase/AKT pathway and subsequently the NF?
Positive_regulation (activating) of ROS Binding (formation) of
16) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.74 Pain Relevance 0.03
The data from our experiments showed that both nicotine and H2O2 had significant increases in the concentrations of MDA formation as compared to the control untreated cells suggesting that both nicotine and H2O2 induced ROS formation in AR42J cells.
Positive_regulation (induced) of ROS Binding (formation) of in AR42J associated with nicotine
17) Confidence 0.05 Published 2008 Journal Tob Induc Dis Section Body Doc Link PMC2556029 Disease Relevance 0.14 Pain Relevance 0.19

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