INT163408

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.56 Pain Relevance 0.13

Golgi apparatus (Crhr2) endoplasmic reticulum (Crhr2) plasma membrane (Crhr2) signal transducer activity (Crhr2)

Crhr2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat spastic colon 2 75.00 Pain 1 25.00

Disease Link Frequency Relevance Heat Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 9 99.76 Stress 10 99.64 Sprains And Strains 2 85.04 Functional Bowel Disorder 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, distal CRFR1 and CRFR2 levels were higher in MS rats but were significantly reduced post OF stress.

Negative_regulation (reduced) of Gene_expression (levels) of CRFR2 associated with stress

1) Confidence 0.27 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07

CRD stimulated decreased expression of CRFR2 in WKY rats alone.

Negative_regulation (decreased) of Gene_expression (expression) of CRFR2

2) Confidence 0.23 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19807869 Disease Relevance 0.50 Pain Relevance 0.05

General Comments

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