INT163461

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.98
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ABL1) protein modification process (ABL1) mitochondrion (ABL1)
nucleolus (ABL1) nucleus (ABL1) DNA binding (ABL1)
Anatomy Link Frequency
neuronal 1
retina 1
ABL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 1 98.88 Very High Very High Very High
Inflammation 6 65.08 Quite High
Pain 9 59.60 Quite High
Glutamate 4 43.28 Quite Low
Nicotine 3 15.60 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
pruritus 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Philadelphia Chromosome 3 98.80 Very High Very High Very High
Disease 46 97.32 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 10 96.40 Very High Very High Very High
Dental Caries 1 96.36 Very High Very High Very High
Myeloid Leukemia 111 94.92 High High
Leukemia 17 94.60 High High
Gastrointestinal Stromal Tumor 6 94.60 High High
Autoimmune Disease 1 92.44 High High
Apoptosis 83 91.20 High High
Myeloproliferative Disorder 135 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electroretinogram and fluorescein angiography investigations have shown the retina to be affected in asymptomatic ABL patients [31].
Regulation (affected) of ABL in retina
1) Confidence 0.32 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 1.21 Pain Relevance 0
Acetylation of Hsp90, a HDAC6 substrate, results in accelerated degredation of HSP90 client proteins, including BCR-ABL, AKT and c-Raf, via the 26S proteosome [65, 76, 89–91].
Regulation (degredation) of BCR-ABL
2) Confidence 0.24 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.51 Pain Relevance 0
The BCR-ABL kinase is constitutively active and via downstream signaling regulates multiple survival pathways, including Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK), PI3/AKT, NF-?
Regulation (regulates) of BCR-ABL
3) Confidence 0.15 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.98 Pain Relevance 0
The expression of p27KIP1 appears to be related to a non-transcriptional mechanism and possibly a consequence of BCR-ABL mediated regulation through the PI3K/AKT pathway [67, 88].
Regulation (regulation) of BCR-ABL
4) Confidence 0.15 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.59 Pain Relevance 0
The number of IKBKAP and ABL1 transcripts was extrapolated automatically by the Sequence Detection System v2.2.2 software (Applied Biosystems).


Regulation (extrapolated) of ABL1
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.08 Pain Relevance 0
The introduction of imatinib, a tyrosine kinase inhibitor mainly targeting BCR-ABL, c-KIT and PDGFR, has profoundly improved the prognosis of both entities, while being surprisingly well tolerated.
Regulation (targeting) of BCR-ABL
6) Confidence 0.11 Published 2009 Journal Drug Saf Section Abstract Doc Link 19810774 Disease Relevance 1.16 Pain Relevance 0.06
These included genes that affect neuronal survival (ABL1 (+), BDNF (?))
Regulation (affect) of ABL1 in neuronal
7) Confidence 0.07 Published 2009 Journal Neurotox Res Section Body Doc Link PMC3006666 Disease Relevance 0.69 Pain Relevance 0.08
Switch pocket kinase inhibitors, such as DCC-2036 and DCC-2157, target the sites involved in controlling the conformation of BCR-ABL, which ultimately controls the activity state of the kinase.
Regulation (controlling) of BCR-ABL
8) Confidence 0.06 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC3000369 Disease Relevance 0.76 Pain Relevance 0

General Comments

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