INT16349

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 16.74
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 3
dentin 3
MC3T3-E1 2
plasma 1
osteoblasts 1
alp (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 5 100.00 Very High Very High Very High
Paracetamol 34 99.80 Very High Very High Very High
Bile 202 98.28 Very High Very High Very High
dexamethasone 6 95.68 Very High Very High Very High
Pain 11 93.44 High High
headache 8 91.92 High High
cva 20 89.76 High High
Inflammation 30 38.64 Quite Low
fibrosis 6 37.08 Quite Low
Arthritis 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypoalbuminemia 1 99.92 Very High Very High Very High
Injury 50 99.88 Very High Very High Very High
Thrombocytopenia 3 99.84 Very High Very High Very High
Osteosclerosis 24 99.82 Very High Very High Very High
Osteoporosis 92 99.48 Very High Very High Very High
Toxicity 116 99.36 Very High Very High Very High
Hepatotoxicity 37 99.36 Very High Very High Very High
Leukocytosis 3 99.02 Very High Very High Very High
Cancer 73 96.96 Very High Very High Very High
Weight Loss 5 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of calcium nodules concomitant with the increase of ALP activity and the activation of the Opn gene showed that the respective cells had differentiated into matured osteoblasts.
Positive_regulation (increase) of ALP in osteoblasts
1) Confidence 0.60 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.24 Pain Relevance 0
ALP has been shown to be a significant independent factor for advanced pancreatic cancer18 and that a 1.8-fold increase of ALP was associated with poor prognosis in a veterans’ cohort, independently of tumor stage.19 Serum albumin was strongly correlated with survival in our multivariable model; this is consistent with the report of Schnelldorfer et al who found that preoperative low albumin was a negative predictor of survival in patients with pancreatic adenocarcinoma undergoing a Whipple procedure; however they failed to prove its independent prognostic value.3
Positive_regulation (increase) of ALP associated with adenocarcinoma and cancer
2) Confidence 0.45 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.33 Pain Relevance 0
ALP activity in mononucleated and MC3T3-E1 cells gradually increased from day 3 to day 14 of osteoblast differentiation.
Positive_regulation (increased) of ALP in MC3T3-E1 associated with osteoporosis
3) Confidence 0.40 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.45 Pain Relevance 0
Laboratory findings revealed that almost all of the patients had a mild leukocytosis, reduced hematocrit and thrombocytopenia; SGOT, ALP, direct bilirubin (DB), total billirubin (TB), BUN, Cr were elevated; hypoalbuminemia was noted.
Positive_regulation (elevated) of ALP associated with leukocytosis, thrombocytopenia and hypoalbuminemia
4) Confidence 0.40 Published 2002 Journal Southeast Asian J. Trop. Med. Public Health Section Abstract Doc Link 12757226 Disease Relevance 2.07 Pain Relevance 0.09
In addition, the serum from the HCAO patient significantly stimulated the MTT intensity, the level of proliferating cell nuclear antigen expression, a proliferation marker, and ALP activity in MC3T3-E1 cells, compared with that from the control subject.
Positive_regulation (stimulated) of ALP in MC3T3-E1 associated with osteosclerosis
5) Confidence 0.39 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 17177144 Disease Relevance 1.51 Pain Relevance 0.08
P. niruri significantly reduced the elevated glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels in the sera of toxicity induced mice, compared with the control group.
Positive_regulation (elevated) of ALP associated with toxicity and glutamate
6) Confidence 0.35 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.37 Pain Relevance 0.43
In conclusion, the present study indicated that the serum from the HCAO patient stimulated TGF-beta-Smad signaling, as well as the proliferation and ALP activity in osteoblastic cells.
Positive_regulation (stimulated) of ALP associated with osteoporosis and osteosclerosis
7) Confidence 0.34 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 17177144 Disease Relevance 1.40 Pain Relevance 0.07
Marked elevation of AST, ALT, ALP, and ACP in liver tissue indicates damage to the tissue.
Positive_regulation (elevation) of ALP in liver
8) Confidence 0.31 Published 2010 Journal Toxicology International Section Body Doc Link PMC2964743 Disease Relevance 0.34 Pain Relevance 0
High levels of ALP (HR: 1.68, 95% CI: 1.09–2.59, p = 0.019), low levels of albumin (HR: 2.17, 95% CI: 1.27–3.69, p = 0.004) and CA 19-9 ?
Positive_regulation (levels) of ALP
9) Confidence 0.30 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.75 Pain Relevance 0
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (induction) of ALP in dentin
10) Confidence 0.21 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.05
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (increased) of ALP in dentin
11) Confidence 0.21 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.05
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (elevated) of ALP in dentin
12) Confidence 0.21 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
The increase in ALP could have been due to liver injury [27] rather than to other pathological reasons (bone disease, malignancies, etc.) because of the corresponding increased activity of GGT [29, 30, 32].
Positive_regulation (increase) of ALP in liver associated with injury and bone cancer
13) Confidence 0.16 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 1.02 Pain Relevance 0.14
ALP can be elevated as a result of toxic effects on bone formation while serum GGT activity is unaffected [29].
Positive_regulation (elevated) of ALP
14) Confidence 0.16 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 0.97 Pain Relevance 0.12
Pretreatment of rats with plant extract (500 mg/kg) significantly lowered (P < 0.05) the respective serum ALP; GOT and GPT levels to 192 +/- 31, 63 +/- 9 and 35 +/- 8. 5.
Positive_regulation (respective) of ALP
15) Confidence 0.13 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.24 Pain Relevance 0.39
Caffeination as well as administration of vitamins A and E caused significant decreases[P < 0.05] in AST and ALP levels in all test groups when co-administered with paracetamol and in ALT level except in the caffeinated paracetamol + Vitamin E group in which ALT and ALP level except in the caffeinated paracetamol + vitamin E group in which ALT and ALP levels significantly increased [P < 0.05].
Neg (except) Positive_regulation (increased) of ALP associated with paracetamol
16) Confidence 0.13 Published 2007 Journal Niger J Physiol Sci Section Abstract Doc Link 18379621 Disease Relevance 0.07 Pain Relevance 1.00
These symptoms were revealed by characteristic biochemical markers such as the increase in the serum creatinine level and the phosphorus concentration for kidney injury, the increase in ALP and GGT levels for liver damage, and the decrease in serum proteins for nutrient deficiency [29–32].
Positive_regulation (increase) of ALP in liver associated with injury and hepatotoxicity
17) Confidence 0.11 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 0.91 Pain Relevance 0.10
mg/kg bodyweight, in addition to a decrease in sodium and chloride ions observed in both sexes, the treated females showed significant increase in creatinine, phosphorus, ALP, and GGT.
Positive_regulation (increase) of ALP
18) Confidence 0.11 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952298 Disease Relevance 0.12 Pain Relevance 0
Our RII protocol mounted a mild level of hepatic toxicity/damage as evidenced by the transient and slight elevation of the AST, ALT, and ALP levels following naked DNA delivery.
Positive_regulation (elevation) of ALP associated with toxicity
19) Confidence 0.05 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC1828073 Disease Relevance 0.23 Pain Relevance 0.04
Serum ALP activity was significantly increased in burned animals and was found to be significantly lowered by Calendula treatment (Table 4).
Positive_regulation (increased) of ALP
20) Confidence 0.05 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2533690 Disease Relevance 0.48 Pain Relevance 0

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