INT163497

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Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 8.40
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Hcn3)
Anatomy Link Frequency
granulosa cells 5
neurons 4
theca cells 2
oocytes 1
Hcn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 264 100.00 Very High Very High Very High
hCN2 44 100.00 Very High Very High Very High
c fibre 24 99.84 Very High Very High Very High
sodium channel 32 81.08 Quite High
Hippocampus 16 57.56 Quite High
member 8 8 39.12 Quite Low
Calcium channel 24 26.88 Quite Low
potassium channel 24 24.40 Low Low
adenocard 16 10.00 Low Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 36 99.84 Very High Very High Very High
Aging 176 99.28 Very High Very High Very High
Diabetes Mellitus 28 98.84 Very High Very High Very High
Diabetic Neuropathy 4 81.76 Quite High
Overdose 8 5.00 Very Low Very Low Very Low
Lifespan 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.
Gene_expression (overexpression) of HCN3 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2
1) Confidence 0.76 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.02 Pain Relevance 0.75
In the sham NG, HCN1, HCN3, and HCN4 were expressed in the A-fiber neurons; and HCN2, HCN3, and HCN4 were expressed in the C-fiber neurons.
Gene_expression (expressed) of HCN3 in neurons associated with ganglion cysts, c fibre, hcn1 and hcn2
2) Confidence 0.76 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 0.99 Pain Relevance 0.62
Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.
Gene_expression (expression) of HCN3 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2
3) Confidence 0.76 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.02 Pain Relevance 0.75
In the sham NG, HCN1, HCN3, and HCN4 were expressed in the A-fiber neurons; and HCN2, HCN3, and HCN4 were expressed in the C-fiber neurons.
Gene_expression (expressed) of HCN3 in neurons associated with ganglion cysts, c fibre, hcn1 and hcn2
4) Confidence 0.59 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.01 Pain Relevance 0.70
HCN3 has different expression patterns in the granulosa cells and theca cells during the aging process, indicating that there is an age-dependent expression of HCN3 in ovarian structures, suggesting that the changes in steroidogenesis during aging might be modulated through this protein.
Gene_expression (expression) of HCN3 in theca cells associated with aging
5) Confidence 0.59 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.65 Pain Relevance 0.16
HCN3 expression decreases during aging in oocytes, granulosa cells of preantral follicles, and in theca cells, suggesting a possible function in the decrease of ovarian function in advancing reproductive age.
Gene_expression (expression) of HCN3 in granulosa cells associated with aging
6) Confidence 0.59 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.78 Pain Relevance 0.14
For HCN1, HCN2, and HCN3, the proteins were found in oocytes and in the granulosa cells of primary, preantral, and antral follicles.
Gene_expression (found) of HCN3 in granulosa cells associated with hcn1 and hcn2
7) Confidence 0.51 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.41
HCN3 has different expression patterns in the granulosa cells and theca cells during the aging process, indicating that there is an age-dependent expression of HCN3 in ovarian structures, suggesting that the changes in steroidogenesis during aging might be modulated through this protein.
Gene_expression (expression) of HCN3 in granulosa cells associated with aging
8) Confidence 0.51 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.59 Pain Relevance 0.17
HCN3 expression are also decreased in the granulosa cells of preantral follicles and theca cells in reproductive aging.
Gene_expression (expression) of HCN3 in granulosa cells associated with aging
9) Confidence 0.46 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.32 Pain Relevance 0.16
HCN3 expression decreases during aging in oocytes, granulosa cells of preantral follicles, and in theca cells, suggesting a possible function in the decrease of ovarian function in advancing reproductive age.
Gene_expression (expression) of HCN3 in oocytes associated with aging
10) Confidence 0.20 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.78 Pain Relevance 0.14
HCN3 has different expression patterns in the granulosa cells and theca cells during the aging process, indicating that there is an age-dependent expression of HCN3 in ovarian structures, suggesting that the changes in steroidogenesis during aging might be modulated through this protein.
Gene_expression (expression) of HCN3 in granulosa cells associated with aging
11) Confidence 0.20 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.65 Pain Relevance 0.16
HCN3 has different expression patterns in the granulosa cells and theca cells during the aging process, indicating that there is an age-dependent expression of HCN3 in ovarian structures, suggesting that the changes in steroidogenesis during aging might be modulated through this protein.
Gene_expression (expression) of HCN3 in theca cells associated with aging
12) Confidence 0.17 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.59 Pain Relevance 0.17

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